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JULY 12, 2018
THE LCGC BLOG
Optimizing Sensitivity in Splitless Capillary GC with FID Detection
It is often possible to achieve better sensitivity and lower limits of detection and quantitation using standard gas chromatography (GC) equipment—here I'm referring to a standard split/splitless injection port and a Flame Ionization Detector (FID). Paying attention to some of the fundamental variables as well as some of the more esoteric considerations can lead to much improved method performance.
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CE in the Biotechnology & Pharmaceutical Industries: 20th Symposium on the Practical Applications for the Analysis of Proteins, Nucleotides & Small Molecules
September 9-12, 2018, Hilton San Francisco Union Square, San Francisco, CA. Join CASSS for CE in the Biotechnology and Pharmaceutical Industries: 20th Symposium on the Practical Applications for the Analysis of Proteins, Nucleotides and Small Molecules on September 9-12, 2018 in San Francisco, CA. This Symposium provides an interactive forum for the discussion of recent development and practical applications of capillary electrophoresis (CE) in the analysis of pharmaceutical and biopharmaceutical industries, including regulatory considerations
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15th Symposium on the Practical Applications of Mass Spectrometry in the Biotechnology Industry
September 9-12, 2018, Hilton San Francisco Union Square, San Francisco, CA Join CASSS for the 15th Symposium on the Practical Applications of Mass Spectrometry in the Biotechnology Industry on September 9-12, 2018 in San Francisco, CA. The focus of this Symposium is the application of mass spectrometry (MS) for product characterization, process monitoring, formulation development and release testing in the pharmaceutical industry.
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Featured Articles
The Promise of Metal–Organic Frameworks for Use in Liquid Chromatography
What can metal–organic frameworks offer for liquid chromatography?
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Make QuEChERS Even Easier
New Q-sep extraction salts from Restek make an easy technique even simpler. Our new, improved design provides the salts in a more granular form, so they flow freely and are easier to pour than powders. The convenient slim packets are easy to open and fit perfectly into extraction tubes, ensuring complete transfer without any spills.
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Current and Future Chromatographic Columns: Is One Column Enough to Rule Them All?
The packed particle bed format still rules LC columns, but advances continue in monoliths. Meanwhile, newer formats are on the horizon, including microfabricated columns and 3D printed columns. This article provides a critical review of all these technologies and demonstrates how further development of chromatographic columns will be of paramount importance in the future.
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PhosphoPeptide & Glycan Desalting
BioPureSPN™ Graphite SPE utilize an activated charcoal bed to both desalt and remove particles. Try BioPureSPN spin columns today for reproducible, high capacity desalting. Now in 96-Well, hybrid weight formats! Tested and proven by leading proteomic laboratories around the world. The Nest Group, Inc. - "Not Just Columns … Answers!"
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Agilent Announces Genohm Acquisition
Agilent Technologies has announced an agreement to acquire Genohm, a developer of highly differentiated, on-premise, and cloud-based software solutions for laboratory management.
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AOAC INTERNATIONAL is a globally recognized, 501(c)(3), independent, third party, not-for-profit association and voluntary consensus standards developing organization founded in 1884. AOAC meets annually and offers scientific sessions, workshops, poster presentations, and an Exhibit Hall to meet a variety of analytical needs. The 132nd AOAC Annual Meeting will take place in Toronto, Ontario, Canada from August 26-29, 2018. For more information,
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MORE FEATURED ARTICLES
Analytical Characterization of Biotherapeutic Products, Part I: Quality Attributes
To ensure the reliable and accurate characterization of biotherapeutics, an arsenal of orthogonal analytical techniques is needed.
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A Guide to Finding the Ideal HPLC Column
HPLC 101 provides definitions and terminology
Answers to common questions when starting your column selection process
"How-To" page helps you choose a product that's right for your application
Care and Storage section advises on maximizing the life of your product
Technical References include resin specifications and useful chromatography calculations
Download our Hamilton HPLC Columns Reference Guide today!
The Use of HILIC Zwitterionic Phase Superficially Porous Particles for Metabolomics Analysis
This article highlights the use of a new HILIC zwitterionic phase on superficially porous particles. A study on the use of a novel mobile-phase additive to achieve superior peak shape and isomer separation is also discussed, as well as improved LC–MS detection capabilities for metabolomics analysis.
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The 38th International Symposium on Halogenated Persistent Organic Pollutants (POPs) & 10th International PCB Workshop – Dioxin 2018, will take place in Krakow between 26th – 31st August.
The Dioxin Symposium and International PCB Workshop are recognized as the leading international POPs meetings for scientists and regulators. This year, apart from the International PCB Workshop, the Dioxin Symposium will also host the Pre-Dioxin Students Session "All POPs & Pseudo-POPs", five major Special Sessions, and other traditional sessions throughout the meeting.
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APPLICATION NOTE
 
Determination of Pesticide Residues in Soil
QuEChERS was successfully used for the extraction and clean-up of 21 pesticides from soil. LC-MS/MS was used for detection and quantitation.
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FEATURED PRODUCTS
 
DAWN HELEOS II
The DAWN® HELEOS® II is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution.
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Backpressure regulation up to 300bar
As an extension to the VICI Jour® Back Pressure Regulators the new JR-BPR3 offers an extended application range. Pressures from 90-300bar (1300-4200psi) are easily manual adjustable. The body is made of stainless steel and the inert membran bar enables the usage of any HPLC mobile phase and of supercritical CO2. The JR-BPR3 can also be mounted into any column oven up to 80°C.
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Molex Polymicro Capillary Configurator
Molex Capillary Configurator 2.0 is a free online tool which helps customers configure fused silica capillary tubing to their specific application needs. Chat with our experts at HPLC —Booth 406.
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Separation & Characterization of Complex Charged Molecules with Electrical Field-Flow Fractionation.
Postnova presents an innovative new simultaneous Electrical and Asymmetrical Flow Field-Flow Fractionation (EAF4) system designed to enhance separation and characterization of biopharmaceutical, environmental and nanomaterials. In an EAF2000 system Electrical and Cross Flow Fields are applied simultaneously enabling separations by particle size and particle charge based on electrophoretic mobility for characterizing complex proteins, antibodies and viruses as well as environmental and charged nanoparticles or polymers.
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CRM for Dissolved Light Hydrocarbon Analysis
A novel MEEP (methane, ethane, ethene and propane) CRM for groundwater analysis, 5 ppm of each gas is provided in a water filled VOA vial with a 90-day shelf life.
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Extensive Portfolio of Consumables
Shimadzu offers a wide range of HPLC and GC consumables, including vials, columns, syringes, and valves, allowing you to obtain high-quality data and keep your lab running efficiently.
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NEW OPTIONS FOR PROTEIN SEPARATIONS
From the originators of Fused-Core® technology, AMT now offers three choices for your mAb LC separations. The NEW HALO® 1000 Å Diphenyl, ES-C18, and C4 with market leading pore size advantage deliver the highest resolution on this fast, efficient, and proven 2.7 µm particle.
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NEW WEBCASTS
Enhanced Simple Sugar Retention and Resolution Using an Innovative and Robust HILIC Phase
Friday, July 13, 2018 at 11 am EDT | 8 am PDT | 1600 BST | 1700 CEST
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High-Throughput, Automated Volatiles Analysis in Air, Polymers, Water and Soil, Using Direct MS
Europe Broadcast: Wednesday, 18 July, 2018 at 1300 BST | 1400 CEST
US Broadcast: Wednesday, July 18, 2018 at 11 am EDT | 10 am CDT | 8 am PDT
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Enhanced Productivity for VOCs Analysis in Water and Soil by Purge & Trap GC-MS
Wednesday 25 July, 2018 at 11 am EDT | 8 am PDT | 1600 BST | 1700 CEST
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Eliminating Toxic Contaminants from Cannabis Extracts Using Proven Chromatography Purification Methods
Thursday, July 26, 2018 at 11:30 am EDT | 10:30 am CDT | 8:30 am PDT
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