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In our March issue:
COLUMNS
GC CONNECTIONS
Controlling Resolution
The experimental factors that control peak resolution and how chromatographers can use this to find an optimum between time, cost, and performance are examined.

COLUMN WATCH
Investigating Reequilibration in HILIC
In this study, reequilibration times in HILIC, for both aqueous–organic gradients and buffer gradients are systematically explored.

FOCUS ON BIOPHARMACEUTICAL ANALYSIS
Analytical Testing of Biosimilars
All agencies have issued varying guidance for the approval of recombinant biosimilars of biopharmaceuticals, and all submittals are considered on a case-by-case basis. This instalment of "Focus on Biopharmaceutical Analysis" looks at the best methodologies for demonstrating their analytical comparability.

PEER-REVIEWED ARTICLES
A Test Mixture for Performance Verification of Multi-User UHPLC–MS Instruments
This article will demonstrate how a simple test mix of carefully selected compounds can facilitate the development of generic walk up UHPLC–MS methods and automated performance monitoring of multiple instruments located in separate laboratories and buildings.

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