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Formulary, A peer-reviewed drug management journal for managed care and hospital decision-makers
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FormularyJournal.com

April 22, 2011

Formulary
Home Medication Safety FDA Actions Latest News Policy Watch Drug Watch
In This Issue
Tocilizumab approved for treatment of SJIA
FDA approves rituximab to treat rare disorders
Topical diclofenac beats oral formulation in safety, tolerability
Successful switch to transdermal buprenorphine for OA pain of the hip, knee
Capsaicin patch reduces neuropathic pain of HIV-associated neuropathy
Transdermal buprenorphine effective for moderate-to-severe chronic low back pain

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Fingolimod (Gilenya) was recently FDA approved in the treatment of relapsing remitting multiple sclerosis (RRMS). How is your health system covering or planning on covering this new oral disease-modifying therapy (DMT)?

1) We will be/are covering it only for patients who have failed injectable DMTs (both in the interferon class and glatiramer acetate).

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Tocilizumab approved for treatment
of SJIA

FDA has approved tocilizumab (Actemra), given alone or in combination with methotrexate, for the treatment of active systemic juvenile idiopathic arthritis in children 2 years of age and older. Read full article.

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FDA approves rituximab to treat rare disorders

FDA has approved rituximab (Rituxan, Genentech, a member of the Roche Group, and Biogen Idec) in combination with glucocorticosteroids for the treatment of 2 forms of anti-neutrophil cytoplasmic antibody-associated vasculitis, Wegener's granulomatosis and microscopic polyangiitis. Read full article.

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Topical diclofenac beats oral formulation in safety, tolerability

Topical diclofenac is safer and better tolerated by patients with osteoarthritis of the knee compared with the oral formulation, according to data presented here at the annual meeting of the American Academy of Pain Medicine, in National Harbor, Md. Read full article.

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Successful switch to transdermal buprenorphine for OA pain of the hip, knee

Conversion to a 7-day regimen of transdermal buprenorphine (Butrans Transdermal System, Purdue Pharma) from a stable regimen of hydrocodone/acetaminophen (Vicodin, Abbott) can be successful in patients with osteoarthritic pain of the hip or knee, according to a study presented at the annual meeting of the American Academy of Pain Medicine, in National Harbor, Md. Read full article.

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Capsaicin patch reduces neuropathic pain of HIV-associated neuropathy

One 30-minute application of a capsaicin (8%) patch (NGX-4010, Qutenza, NeurogesX) can reduce neuropathic pain due to HIV-associated neuropathy, according to data presented here at the annual meeting of the American Academy of Pain Medicine, in National Harbor, Md. Read full article.

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Transdermal buprenorphine effective for moderate-to-severe chronic low back pain

Transdermal buprenorphine (Butrans Transdermal System, Purdue Pharma) was superior to placebo in treating opioid-naïve patients with moderate-to-severe chronic low back pain, according to study results presented at the annual meeting of the American Academy of Pain Medicine, in National Harbor, Md. Read full article.

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  5. FDA Pipeline Preview, March 2011 (Contrave, rabeprazole sodium extended-release capsules, Avodart, Mu Delta, Carfilzomib, Vascugel, INX-0818, vosaroxin, Acurox, fidaxomicin, melanoma cancer vaccine, NSI-566RSC, Regorafenib)
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