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Formulary, A peer-reviewed drug management journal for managed care and hospital decision-makers
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FormularyJournal.com

September 23, 2011

Formulary
Home Medication Safety FDA Actions Latest News Policy Watch Drug Watch
In This Issue
First-ever CAP guidelines for infants and children
FDA approves 2 new indications for denosumab
Lixisenatide 1-step as effective as 2-step regimen in improving glycemic control in type 2 diabetes
FDA oncology office realigns by expertise, disease areas
NSAIDs increase miscarriage risk in early pregnancy
Warfarin patients should be monitored for acetaminophen interactions

Survey

This month we would like to know...

With the recent announcement of Medco's acquisition by Express Scripts, potentially bringing 2 of the nation's largest PBMs together, what do you see as the most significant implications of such consolidation for the industry?

a) Enhanced competition within the industry, inevitably translating to even lower drug costs for PBM payer clients.

b) Unfair advantages for Express Scripts based upon its size, thus reducing competition and potentially increasing long-term costs for payers.

c) Increased pressures on retail pharmacies forcing more pharmacies out of business.

d) Increased quality of PBM clinical, analytic and administrative services across the industry, as other PBMs strive to stay competitive.

e) Minimal, if any, impact.

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First-ever CAP guidelines for infants and children

The Pediatric Infectious Disease Society and the Infectious Disease Society of America have developed the first-ever guidelines on diagnosing and treating community-acquired pneumonia (CAP) in infants and children. The guideline was published online August 30th in Clinical Infectious Disease. Read full article.

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Formulary Staff

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FDA approves 2 new indications for denosumab

FDA approved 2 new indications for denosumab (Prolia, Amgen). Read full article.

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Lixisenatide 1-step as effective as 2-step regimen in improving glycemic control in type 2 diabetes

Lixisenatide (Lyxumia, Sanofi), a once-daily GLP-1 receptor agonist under development for type 2 diabetes, achieved its primary efficacy end point of significant HbA1c reduction versus placebo in patients uncontrolled on metformin. Read full article.

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FDA oncology office realigns by expertise, disease areas

FDA announced that the Center for Drug Evaluation and Research's Office of Oncology Drug Products will now be called the Office of Hematology and Oncology Products. Read full article.

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NSAIDs increase miscarriage risk in early pregnancy

Nonsteroidal anti-inflammatory drugs (NSAIDs) should be used with caution during pregnancy, as exposure may increase the risk of spontaneous abortion, reported a study published online September 6 in the Canadian Medical Association Journal. Read full article.

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Warfarin patients should be monitored for acetaminophen interactions

An interaction between warfarin and acetaminophen may result in significant elevations of international normalized ratio, putting patients at increased risk for hemorrhagic complications, reported a literature review published in the June issue of Pharmacotherapy. Read full article.

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