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Formulary E-News
December 10, 2010
Formulary
 
In this issue
Metformin lowers mortality
Tesamorelin approval
Paricalcitol reduces albuminuria
Propoxyphene withdrawal
   
 

Survey

This month we would like to know...

Egrifta (tesamorelin) was recently FDA-approved to treat HIV-associated lipodystrophy (aka, visceral adipose tissue [VAT]), which will be available in January 2011. VAT has been associated with adverse cardiovascular outcomes. How is your health-system covering or planning on covering this injectable drug product?

a) We will be/are covering it as a medically necessary drug if patient's meet criteria for use.
   
b) We will be/are covering it as a medically necessary drug for all HIV patients.
   
c) We will not be covering it at all since it is a cosmetic product.
   
d) We have not yet decided how to cover this product.
   

Click here to vote

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Therapy Update

Nonanthracycline regimens for adjuvant treatment of operable breast cancer
Nonanthracycline-containing chemotherapy regimens for the adjuvant treatment of operable stage I to III  breast cancer are discussed, including efficacy and toxicity results from recent randomized clinical trials comparing anthracycline to nonanthracycline-containing  regimens. More...

Metformin may lower mortality in patients with diabetes and heart failure
Metformin, either alone or in combination with sulfonylurea, appears to increase 1-year and long-term survival in patients with type 2 diabetes mellitus (T2DM) and chronic heart failure (CHF), according to research published in the October 1 issue of the American Journal of Cardiology, HealthDay News reported. More...
FDA approves tesamorelin for HIV patients with lipodystrophy
Canada-based Theratechnologies announced that FDA has approved tesamorelin (Egrifta) to treat HIV patients with lipodystrophy. The condition is associated with many antiretroviral drugs used to treat HIV. More...
Paricalcitol found to reduce albuminuria in type 2 diabetes
In a multinational, placebo-controlled, double-blind trial, the selective vitamin D receptor activator paricalcitol (Zemplar, Abbott Laboratories), at doses of 1 µg or 2 µg daily, reduced albuminuria in patients with type 2 diabetes, who were already being treated with renin-angiotensin-aldosterone system inhibitors. This research was published online November 4 in The Lancet, HealthDay News reported. More...
Manufacturer agrees to withdraw propoxyphene from the market
Xanodyne Pharmaceuticals has agreed to withdraw propoxyphene (Darvon and Darvocet) from the US market at the request of FDA. FDA also has informed generic manufacturers of Xanodyne’s decision, and they will be removing their propoxyphene-containing products from the market as well. More...

Top 5 Web Stories
Focus on lurasidone: A new atypical antipsychotic for the treatment of schizophrenia
Attention deficit hyperactivity disorder: More than a child's disease
FDA Actions in Brief November 2010 (Latuda, Ofirmev, Cymbalta, Botox, Pradaxa, Afinitor, Teflaro, Herceptin, Kapvay)
Olmesartan medoxomil, amlodipine, and hydrochlorothiazide (Tribenzor): A new 3-drug combination product for the treatment of hypertension
FDA Pipeline Preview, November 2010 (Qnexa, Linjeta, JZP-6, Bydureon, Zalbin, Staccato loxapine, Tapentadol extended-release oral analgesic, AVP-21D9, 1% tenofovir vaginal gel, AFM 13, hGH-CTP, Rozrolimupab, Nefecon, SB1518 JAK2 inhibitor)

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