Featured Application Note:
Eluent Generation for Carbohydrate Analysis
Yan Liu, Petr Jandik, Victor Barreto, and Chris Pohl
A new method for electrolytically generating multi-component IC eluent gradients for carbohydrate and amino acid analysis. KOH and MSA eluent generation cartridges are used in tandem to produce eluents containing KOH and potassium methanesulfonate for separation before amperometric detection. |
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The Determination of Low Levels of Benzene, Toluene, Ethylbenzene, Xylenes, and Styrene in Olive Oil
Andrew Tipler, PerkinElmer®, Inc.
Levels of benzene, toluene, ethylbenzene, xylenes, and styrene (BTEXS) are a concern in olive oil. These compounds find their way into olive trees and hence into the olives and olive oil mainly as a result of emissions from vehicles, bonfires, and paints into ambient air near the orchards. This application note describes an easy to perform method using PerkinElmer® Clarus® SQ 8 GC–MS with a TurboMatrix™ 110 headspace sampler to achieve detection limits below 0.5 ng/g. |
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Optimizing Performance of the Agilent 1290 Infinity LC System Using 1-mm id Columns
Sonja Schneider, Agilent Technologies
The performance of the Agilent 1290 Infinity LC system was optimized for the analysis of peptides using 1-mm id columns together with the Ultra-low Dispersion Kit. |
Fast Simulation of Drug Metabolism Using Electrochemistry-MS
A. Kraj, H-J. Brouwer, M. Eysberg, and J-P. Chervet, Antec
For faster, better, and superior simulation of drug metabolism, Antec has developed a dedicated electrochemistry system, called ROXY™ EC. The system is used up-front MS and allows for the generation and screening of potential metabolites, mimicking P450 enzymatic reactions in a few seconds without any biological interferences. |
USP Method Transfer of Donepezil Tablets
Mia Summers and Kenneth J. Fountain, Waters Corporation
This application demonstrates the transfer of the organic impurities USP method for donepezil tablets from HPLC to UPLC. A routine use study using conditions typical of a QC laboratory protocol is performed with the UPLC method to assess the long-term robustness of the method. The effects of repeated injection of a formulated sample on method robustness are also considered. |
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Absolute molar masses for phenol formaldehyde resins
Dr. Daniela Held, Friedhelm Gores, PSS Polymer Standards Service GmbH
Phenol formaldehyde resins are formed by a step-growth polymerization. GPC/SEC with RIand UV detection is often used to characterize resins and to quantify the amount of differentoligomeric species. Additional information is available if an ESI-MS-spectrometer is on-lineattached to the GPC/SEC system. This allows to identify oligomeric species and to learnabout the degree of CH2-OH substitution. |
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Antibody Drug Conjugate Analysis
Wyatt Technology
There has been a significant resurgence in the development of antibody-drug conjugates (ADC) as target-directed therapeutic agents for cancer treatment. Among the factors critical to effective ADC design is the drug antibody ratio (DAR). The DAR describes the degree of drug addition, which directly impacts both potency and potential toxicity of the therapeutic, and can have significant effects on properties such as stability and aggregation. Determination of DAR is, therefore, of critical importance in the development of novel ADC therapeutics and this note shows how multiangle light scattering can help determine the DAR. |
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One Step Extraction, Cleanup and Concentration of PCBs in Soil
Phil Bassignani, FMS, Inc.
Due to PCB's toxicity and classification as a persistent organic pollutant, PCB production was banned by the United States Congress in 1979 and by the Stockholm Convention on Persistent Organic Pollutants in 2001.PCBs have low water solubility and are largely chemically inert, making them extremely resistant to oxidation. These properties enable PCBs to with stand environmental degradation, and build up in soil and river sediment. This note discusses automating the extraction,cleanup and concentration of soil samples in one step. |
Extraction of Synthetic Cannabinoids (SPICE) and Metabolites from Urine, Plasma and Whole Blood using ISOLUTE® SLE+
Victor Vandell, Frank Kero & Gavin Jones, Biotage AB, Sweden
This application note describes the extraction and quantitation of Cannabimimetic Naphthoylindoles (Synthetic Cannabinoids) and their metabolites (JWH Series) from various matrices using Supported Liquid Extraction (SLE). The recoveries obtained for the synthetic
cannabinoids parent and metabolites ranged from 70-98 %.
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Direct desorption of VOCs and SVOCs from leather furnishings
Caroline Widdowson, Markes International Ltd
Troubleshooting problems affecting textiles and other furnishings can be extremely challenging for the analyst. Issues such as discoloration, odour, unsatisfactory or uneven resistance to wear, and inadequate waterproofing can potentially be caused by a wide range of external factors, as well as by product treatment or processing. This Application Note demonstrates the direct desorption of volatile and semi-volatile organic compounds (VOCs and SVOCs) from leather furnishings, in order to identify the cause of discoloration. |
Sample Preparation for MALDI Imaging with the SunCollect System
Guenes Barka and Dominic Baeumlisberger, SunChrom GmbH
The SunCollect sprayer supports and simplifies your sample preparation workflow for MALDI imaging measurements. The homogeneous and robust spraying process enables the production of consistent and high-quality results. |
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Intestinal permeability test using ion chromatography
Benedikt Galliker and Alfred Steinbach, Metrohm AG
The lactulose/mannitol test facilitates to diagnose leaky-gut syndrome and associated chronic inflammatory bowel diseases. The test stipulates that lactulose and mannitol concentrations in urine samples are accurately and quickly determined. This is best achieved using ion chromatography with pulsed amperometric detection. |
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Mike Tessalone
+1 732 346 3016 | Email
Lindsay Jones
+44 1244 629316 | Email
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