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Featured Application Note:
Separate Glycans by Simultaneous Charge, Size and Polarity
Udayanath Aich, Julian Saba, Xiaodong Liu, Srinivasa Rao, and Chris Pohl,
Thermo Fisher Scientific
LC–MS analysis of fluorescently labelled N-glycans released from proteins on a novel Thermo Scientific™ GlycanPac™ AXH-1 column. The column has unique selectivity and provides separation of glycans based on simultaneous charge, size, and polarity — offering high-resolution and high-throughput analysis. Read More |
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Detection of Trace-Level Herbicides in Water by Online SPE
Bettina Schuhn, Agilent Technologies
Analysis of trace-level herbicides in water using the Agilent 1200 Infinity Series Online SPE solution coupled with triple quadrupole MS detection in conformance to the German DIN standard 38407-36. Read More |
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Macrolides in Honey Using Agilent Bond Elut Plexa SPE, Poroshell 120, and LC–MS-MS
Chen-Hao (Andy) Zhai and Rong-jie Fu, Agilent Technologies
A method for the simultaneous determination of macrolide residues of spiramycin, tilmicosin, oleandomycin, erythromycin, tylosin, leucomycin, roxithromycin, and josamycin in honey was developed and validated. The method provides trace level limits of detection for all macrolides in honey. The dynamic calibration ranges for these compounds was obtained from 0.1 to 100 ng/g and overall recoveries ranged from 67.8% to 106.6% with RSD values between 1.9% and 10.7%. Read More |
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Synthetic Cannabinoids from Whole Blood
Jonathan P. Danaceau, Erin E. Chambers, and Kenneth J. Fountain, Waters Corporation
This application note details a strategy for the successful extraction and analysis of representatives of several different classes of synthetic cannabinoids from whole blood samples for forensic toxicology. Twenty-two synthetic cannabinoids and metabolites were extracted from whole blood samples using a rapid and universal sample preparation strategy that provides effective sample cleanup and is generic enough to use on a variety of compounds with different chemical properties. Read More |
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Advantages of a TD–GC–TOF MS Approach for Detecting Trace-Level Odorants in Polluted Air
Steve Smith, Laura McGregor, and David Barden, Markes International Ltd
This application note describes the use of TOF MS (BenchTOF-dx™) in conjunction with thermal desorption–gas chromatography to analyze air taken from the outflow of a biological waste processing plant. At the same time, the value of TargetView™ software is demonstrated by applying it to a targeted search for odorous sulphur compounds. A particular feature of this study is the re-collection capability of the TD system, which offers an exceptionally wide dynamic range. Initial high-split analysis enables quantitative measurement of the most abundant species, and subsequent low-split analysis allows trace-level constituents to be measured in the same sample. Read More |
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SEC-MALS of Silicones
Wyatt Technology
Polydimethylsiloxane is the world’s most common silicone. Its applications range from contact lenses and medical devices to elastomers, caulking, lubricating oils and heat resistant tiles. For all of its applications, the weight-average molar mass (and its distributions) is directly associated with the performance of the product. This note shows how Wyatt Technology’s SEC-MALS detectors successfully characterized the samples without resorting to column calibration or reference standards. Read More |
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Characterizing Polysaccharide Structure Using SEC-MALS and Intrinsic Viscosity
Malvern Instruments
In this application note, molecular weight data from the Viscotek SEC-MALS 20 is combined with measurements of Rg and IV to study the structure of different polysaccharides including pullulan, dextran, hydroxypropyl cellulose (HPC), pectin and gum Arabic. The differences between conformation and Mark-Houwink plots are also studied. Read More |
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Automated Solid Phase Extraction and Concentration for the Determination of Nitrosamines in Drinking Water
Phillip Bassignani, FMS, Inc.
Nitrosamines are a group of chemical compounds regulated due to their carcinogenic characteristics. Nitrosamines have many sources including widespread usage in the manufacturing of rubber products, as well as cosmetics. They have also been demonstrated to form from reactions between food preservatives and amines. In drinking water, established limits are low (<1 ng/L), requiring detection by a Mass Spectrometer in the chemical ionization mode. Read More |
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Extraction of Acrylamide from Coffee using ISOLUTE SLE+ prior to LC–MS-MS analysis
Alan Edgington, and Lee Williams, Biotage AB, Sweden
This application note demonstrates a clean, rapid, robust and sensitive extraction protocol for the analysis of acrylamide from coffee using SLE+ columns. Levels of sensitivity were achieved down to as low as 1 ng/mL for coffee in solution. Read More |
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