LCGC Europe Single Sponsored Application Note Alert
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Implementation of a Walk-Up High-Pressure Capillary Ion Chromatograph for the Fast Separation of Pharmaceutical Relevant Inorganic Anions and Cations
Terri Christison, John E. Madden, Fei Pang, and Khalil Divan, Thermo Fisher Scientific
Ion chromatography (IC) with suppressed conductivity detection is a well-established technique for the determination of inorganic and organic ions in pharmaceuticals. The recent development of high-pressure capillary IC brings additional advantages for the analysis of inorganic ions. Read More
Combining the Synergies of Ion Chromatography and Inductively Coupled Plasma to Identify Mercury Contamination in Herbal Medicines
Terri Christison, Frank Hoefler, and Linda Lopez, Thermo Fisher Scientific
Combining the synergies of two analytical techniques, speciation by ion chromatography (IC) and total multi-elemental analysis by inductively coupled plasma mass spectroscopy (ICP-MS), were used to solve the source and clinical cause of a mercury poisoning cluster.
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HPCL
Determination of Iodide and Iodate in Soy- and Milk-Based Infant Formulas
Lipika Basumallick and Jeffrey Rohrer, Thermo Fisher Scientific
Iodine is an important micronutrient essential for the production of thyroid hormones that are involved in the regulation of many key biochemical reactions. Iodine deficiency can lead to varying degrees of growth and developmental abnormalities in children and adults, including such illnesses as goiter and cretinism. As iodine is primarily absorbed from our diet, supplementation of iodine in food is a common practice. Read More
Determination of Trace Sodium in Cranberry Powder
Brian De Borba and Jeffrey Rohrer, Thermo Fisher Scientific Inc
Cranberry powder contains organic acids, proanthocyanidins, and polyphenols. The powders are generally recognized as safe (GRAS) and can be used in beverages, foods, cosmetics, and supplements. This application note describes the determination of organic acids in cranberry extracts. Organic acids in cranberries impart flavors and their specific ratios can be used to detect adulteration. Read More

Fast Separations of Anions and Organic Acids in a Carbonated Beverage Using High-Pressure Capillary IC
Terri Christison, Fei Pang, Weerapong Worawirunwong, and Linda Lopez, Thermo Fisher Scientific
Determinations of organic acids in beverages are important to the beverage industry because these acidulants and flavoring agents maintain beverage freshness, minimize microbiological growth, and add a characteristic flavor.
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HPCL
Direct Determination of Small Organic Acids in Sea Water by IC-MS
Marcus Miller and William Schnute, Thermo Fisher Scientific
Studies show that low molecular weight species in aquatic environments are important sources of carbon for marine bacteria. Short-chain organic acids in the marine environment play important roles in adjusting the pH value, forming a variety of complexes, and then increasing the solubility of trace metals in sea water. Ion chromatography-mass spectrometry (IC-MS) provides a faster, more direct approach that does not require sample pretreatment. Read More
Efficient and Fast Separations of Inorganic Anions in Water Samples Using a 4 µm Particle Size Microbore Column with a High-Pressure Ion Chromatography System
Carl Fisher, Terri Christison, Barbara Shao, and Linda Lopez, Thermo Fisher Scientific
4 µm columns allow for an optimal combination of fast speed and high resolution ion chromatography. This technical note presents the advantages of using these small-particle columns in all available formats: standard (4 mm i.d.), microbore (2 mm i.d.), and capillary (0.4 mm i.d.) to obtain fast and efficient HPIC separations of inorganic anions in municipal drinking and wastewater samples. Read More

Improved Determination of Trace Perchlorate in Drinking Water Using 2D-IC
Lillian Chen, Brian De Borba, and Jeffrey Rohrer, Thermo Fisher Scientific
Perchlorate is identified as an environmental contaminant found in drinking, ground, and surface waters. The origins of perchlorate are both natural and anthropogenic. Ion chromatography (IC) is recognized as an effective tool for the determination of perchlorate in drinking water and other samples. Read More


 
HPCL

Quantitative Profiling of Nucleotides Using Capillary IC-MS-MS
Leo Jinyuan Wang, Lijuan Fu, Yinsheng Wang, Hongxia (Jessica) Wang, Bill Schnute, and Guifeng Jiang, Thermo Fisher Scientific and University of California
Nucleoside and nucleotide analogues constitute a major class of antiviral and antitumor agents. Thermo Scientific™ Dionex™ ICS-5000 Reagent-Free™ IC (RFIC™) system enables seamless coupling of highly efficient IC separations with electrospray ionization MS (ESI-MS) detection. Read More