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| Sponsored by: Thermo Fisher Scientific |
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Multicomponent Adjuvants
Adjuvants help promote the effectiveness of vaccines but can be difficult to analyze due to their structurally-diverse components. Charged aerosol detection can characterize several adjuvant components simultaneously, including triterpenoid saponins, cholesterol, phospholipids, and surfactants, with LODs in the low μg/mL (ng on-column) range.
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pH Gradient Separation Platform for MAbs
In the fast-paced drug development environment, a method that detects the majority of monoclonal antibody analyses is a must. The novel linear pH gradient for cation-exchange chromatography platform enabled high-resolution, fast, and rugged separation of MAb charge-variant analysis. Read More |
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Antibiotics in Dried Distillers Grains
Distillers grain is a valuable product to the livestock industry because it is a rich source of protein, fat, minerals, and vitamins, thus making it an excellent feed supplement for livestock and poultry. Bacterial contamination is a concern for ethanol production. Antibiotics, such as virginiamycin, penicillin, and erythromycin, are commonly used during fermentation to inhibit bacterial growth. This method using a multistep sample extraction demonstrated efficient separation and resolution of the target antibiotics within 15 min. Read More |
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Herb & Fruit Juice Adulteration and Authenticity
Identification of adulteration and authenticity is a major issue for the food and beverage industry. Coulometric array detection was used to generate untargeted metabolomic fingerprints of herb and fruit juice samples that were then interrogated using pattern recognition analysis. This approach could readily detect as little as 5% adulteration of herb blends or orange juice (either blended with the addition of orange peel or pulpwash). The technique also classified orange juice samples by varietal and geographic growing region. Read More |
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Silicone Oils
Silicone oils are thermally stable, relatively inert, and are generally nontoxic, making them useful as oils, greases, lubricants, antifoaming agents, and coatings in electronics, hydraulic systems, and many consumer products. These oils are notoriously difficult to analyze: within the class they have similar structures and often lack chromophores. Simple, direct, sensitive HPLC methods were developed that are capable of either characterizing or quantifying silicone oils in heating bath oils and OTC products such as shampoo, conditioner, and gas relief products. Read More |
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Surfactants in a Variety of Products
Surfactants are notoriously difficult to analyze, within the class they have similar structures and often lack chromophores. Simple, direct HPLC methods were developed that are capable of either characterizing or quantifying surfactants in machine oils and OTC products. Samples were merely diluted and analyzed. Read More |
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Rapid Analysis of Aminothiols
Glutathione and glutathione disulfide are biochemically important sulfur-containing compounds that occur in vivo and their measurement is technically challenging. This rapid method is capable of accurately and simultaneously determining these compounds using UHPLC with a BDD working electrode, thus providing shorter cycle times between samples, improved resolution, and sharper peaks. Read More |
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API and Counterion: Tartaric Acid and Tolterodine
Tolterodine tartrate is a medication that is used to treat urinary urgency, reducing the frequency of passing urine and urinary incontinence. This accurate and reproducible HPLC method demonstrates a single-injection determination of tolterodine and tartrate — the API and its counterion — in an encapsulated drug product containing tolterodine tartrate. The method requires only 13 min per analysis. Read More |
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