COLUMNS
SAMPLE PREP PERSPECTIVES
Ionic Liquids and Their Applications in Sample Preparation
Tien D. Ho, Honglian Yu, William T.S. Cole, and Jared L. Anderson
Ionic liquids have tunable selectivity for specific classes of analytes, giving them distinct advantages over organic solvents.

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LC TROUBLESHOOTING
The Importance of the Sample Matrix
John W. Dolan
How to account for the sample matrix when developing a method

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MS — THE PRACTICAL ART
Identifying “Known Unknowns” in Commercial Products by Mass Spectrometry
James L. Little, Curtis D. Cleven, and Adam S. Howard
A systematic approach for the identification of nontargeted species, searching both mass spectral and “spectra-less” databases.

THE HISTORY OF CHROMATOGRAPHY
Man of the Masses
Kate Yu
An interview with Fred McLafferty, professor emeritus at Cornell University, about his pioneering career in mass spectrometry.

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THE ESSENTIALS
Troubleshooting GC Gas Supply, Sample Preparation, and Inlets
The first three important stages in any GC analysis are explained.

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ARTICLES
Solvent Selection in Countercurrent Chromatography Using Small-Volume Hydrostatic Columns
Karine Faure, Nazim Mekaoui, Jeremy Meucci, and Alain Berthod
How to use small columns to test potential biphasic liquid systems for use in large-scale countercurrent chromatography separations.

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LC–MS-Compatible Separation of Polar Compounds Using Silica Hydride Columns
Joshua E. Young, Hong Nhung Nguyen, Maria T. Matyska, Joseph J. Pesek
A guide to using HPLC in an iterative form to clarify decision-making during method development.

Editors' Series: HILIC: A Critical Evaluation
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