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In our June issue:
COLUMNS
LC TROUBLESHOOTING
Internal Standard Calibration Problems
John Dolan addresses readers’ questions regarding problems related to internal standard calibration of liquid chromatography methods.

COLUMN WATCH
The State of Superficially Porous Particles in LC
The use of superficially porous particles (SPPs) in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent. This instalment aims to provide highlights of these recent trends.

QUESTIONS OF QUALITY
Drawing the Line
A question that keeps raising its head when working in a regulated laboratory is can chromatographers integrate peaks manually? If they can, when can they do it? If they can manually integrate, when should they not do it?

PERSPECTIVES IN MODERN HPLC
High-Throughput Purification in Drug Development
This instalment provides an overview of modern practices of high throughput purification to support small-molecule drug discovery.

PEER-REVIEWED ARTICLES
Translating Methods from HPLC to UHPLC
The numerous advantages of translating gradient chromatographic methods between the differing formats of LC are explored and discussed. Various potential pitfalls may result in selectivity differences, changes in efficiency, and failure to meet resolution system suitability criteria.

UPCOMING WEBCASTS

Editors' Series: Part 1: Theory and Practice of Two-Dimensional Liquid Chromatography
Tuesday, June 16, 2015
9 am EDT, 2 pm BST, 3 pm CEST
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Four Part Webcast Series: Pesticide Residue Analysis: Tips and Tricks for the Whole Workflow: Maximizing Analysis Efficiency through New GC–MS Approaches
Wednesday, June 17, 2015
8:00 am PDT/ 11:00 am EDT/ 4:00 pm BST/ 5:00 pm CEST
Register>>

Three Part Webcast Series: MAb Charge Heterogeneity Analysis by CZE Part 1: Results of an Intercompany Robustness Study
Thursday, June 18 2015
7 am PDT, 10 am EDT, 16:00 CEST
Register>>

A Faster, More Sensitive Sample Preparation Solution for Bioanalytical Samples
Tuesday, June 23 2015
8:00 am PDT/ 10:00 am CDT/ 11:00 am EDT
Register>>

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