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In our August issue:
COLUMNS
LC TROUBLESHOOTING
Overload in LC
John Dolan discusses how to distinguish between liquid chromatography (LC) column overload and detector overload.
COLUMN WATCH
Modern SFC
This review focuses on the advances in theory, instrumentation, and novel applications of supercritical fluid chromatography (SFC).
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Million Metabolome Project, an ambitious milestone for Exposome Research
Ultra high resolution, accurate mass (UHRAM) mass spectrometry, based on the Thermo Scientific™ Orbitrap™ technology, is a powerful new approach to high throughput screening and quantitation in complex sample matrices. To learn more about how UHRAM is used in the Million Metabolome Project, an ambitious milestone for Exposome Research, LCGC talked with Dean Jones of Emory University.
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SAMPLE PREPARATION PERSPECTIVES
Lipid Extraction Methods
Recently, Nature and Science Citation Index listed the 100 most cited research papers of all time. Two of these are the classic Bligh Dyer and Folch lipid extraction methods from the late 1950s. Sample Preparation Perspectives Editor Douglas Raynie takes a look at the lasting impact of these papers and explores the current state of lipid extractions, including lipidomics.
PERSPECTIVES IN MODERN HPLC
High-Throughput Characterization in Drug Discovery
A review of the practice of separation science in high-throughput characterization and quality control of drug development, illustrated with a case study.
PEER-REVIEWED ARTICLE
New Directions in GC
Ionic liquids (ILs) have become recognized in gas chromatography (GC) as stable and highly polar stationary phases with a wide application range. Having customizable molecular structures, ILs also offer a particular tunability that provides additional selectivity, and therefore may improve separation for neighbouring analytes. This article presents specific properties of IL phase capillary GC columns, including polarity scale and inner surface morphologies of IL columns.
UPCOMING WEBCASTS

Combating Food Fraud Through Improved Chromatography
Tuesday, September 15, 2015
8 am PDT/ 10 am CDT/ 11 am EDT

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Characterization of Prebiotics UsingHigh-Performance Anion Exchange Chromatography (HPAEC) at High pH Coupled with Pulsed Electrochemical Detection (PED)
Wednesday, September 23, 2015
8 am PDT/ 11 am EDT/ 15:00 GMT

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issue:
Pesticide Testing

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