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March 2015 GPC Hyphenated HPLC GC Sample Prep   Understanding Antibody and Viral Glycoprotein Interactions Using CG–MALS Viral glycoproteins are often the only antigens found on the viral surface, and are therefore key targets for neutralizing antibodies. Analyzing the type and affinity of the different molecular interactions that can occur is essential for understanding what makes a good neutralizing antibody and how these interactions can be utilized in post-exposure treatments as well as vaccine development. Download the app note Differentiation of Polymer Branching and Composition using The Mark–Houwink Plot This application note describes how to separate the effects of a structural difference induced by a compositional change to a polymer (for example, substitution), and the structural change induced by polymer chain branching using multi-detection GPC/SEC and Malvern's new OMNISEC system. Download the app note Controlled Reduction of Disulphide Bonds in Protein Therapeutics Using On-Line EC–MS The electrochemically-assisted reduction of disulphide bonds followed by on-line mass spectrometric (MS) detection is presented without reagent or enzymes. The method is based on square-wave potential pulses applied on a new type of proprietary working electrode made from titanium alloy. Download the app note Analysis of Explosives by UHPLC with Dual-Wavelength Detection This application note shows the analysis of 20 explosives using the Agilent 1290 Infinity II Variable Wavelength Detector (VWD) in dual-wavelength mode using 254 and 214 nm. Download the app note The Principles and Applications of the Unique Aerosol Detector, NQAD NQAD was developed as a novel aerosol-based universal detector using water condensation particle counter (WCPC) technology. NQAD provides high performance with unparalleled wide linearity (3 orders of magnitude) and sensitivity. This application note describes the principle of NQAD and it’s applications in fatty acid, amino acid, and grape seed analysis. Download the app note Monitoring Air at Refinery Perimeters Using US EPA Method 325 Do you need to comply with the forthcoming US EPA Method 325 for refinery fence-line monitoring of volatile organic compounds (VOCs)? This application note from Markes International describes a stepwise approach to complying with the new method, and includes tips on how to deploy the required tube-based passive samplers, analyze your samples and clean the samplers. It also outlines a powerful RFID-based approach to tracking your samples from field to lab. Download the app note The Analysis of Chlorinated Dioxins Using Automated Pressurized Liquid Extraction, Multicolumn Cleanup, and Concentration Traditional dioxin/difuran extraction procedures require 24 hour soxlet extraction, and a wide array of manual sorbent cleanup procedures, each with their own evaporation step.  This results in extensive manual prep hours, high levels of potential error, and increased potential for background or cross-contamination of samples.  By utilizing the FMS total prep process, extraction and cleanup processes are automated into a high efficiency process capable of delivering same day analysis of these samples. Download the app note Extraction of Drugs of Abuse from Hair using ISOLUTE® SLE+ Hair is regarded as complementary to blood and urine samples in forensics because it is a very stable matrix and offers detection days to years post-exposure. In this application, supported liquid extraction (SLE) is demonstrated for the determination of drugs in hair using Biotage ISOLUTE ® SLE+ (with positive pressure) and compared with traditional solid-phase extraction (SPE). Download the app note   Go to Application Note Library Subscribe to the Application Note Alert LCE Print Edition LCE Digital Edition