LCGC Europe Application Note Alert
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Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS
Viral glycoproteins are often the only antigen found on the viral surface, and are therefore key targets for neutralizing antibodies. Analyzing the type and affinity of the different molecular interactions that can occur is essential for understanding what makes a good neutralizing antibody and how these interactions can be utilized in post-exposure treatments as well as vaccine development.
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Comprehensive Characterization of Essential Oil by GC×GC–TOF MS
This application note shows that GCxGC–TOF MS can be used as a high-performance tool for comprehensively screening the total composition of essential oils. “Reference-quality” spectra for both high- and low-concentration components are produced, with confident identification and accurate quantitation being achieved for complex mixtures. Furthermore, Select-eV soft ionisation delivers an extra level of information on sample composition as well as improved sensitivity, resulting in lower detection limits.
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Essential Oils Quantitative Profiling GCx2GC–MS-FID
This application note demonstrates the benefits and potential of comprehensive two-dimensional gas chromatography (GCxGC) simultaneously coupled with mass spectrometry (MS) and FID detection— using MEGA GC columns (MS, FAST and Chiral DEX columns) for detailed analysis, identification, and quantitation of medium-to-high complexity mixtures.
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Solid-Phase Extraction and Analysis Of Organochlorine Pesticides and Inline Cleanup from Water
In water samples, OCPs are monitored by the U.S. Environmental Protection Agency by various methods including methods EPA 508, EPA 608 and EPA 8081. The use of solid-phase extraction (SPE) can rapidly increase both extraction efficiency and reduce lab solvent usage. By implementing the FMS TurboTrace® ABN system with its dual cartridge functionality, an in-line Florisil cartridge can be added to perform automated extract clean-up during the elution step.
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Determination of Anabolic Steroids in Horse Urine by SPE and LC–MS–MS
Performance-enhancing anabolic steroids are making headlines in many professional and Olympic sport settings including the horse racing industry. Currently, urine is a matrix of choice for quantitative analysis in equine drug testing in spite of its analytically challenging, viscous nature. In this study, hydrolyzed horse urine samples were adjusted to pH 7 and extracted using a mixed-mode SPE cartridge (C8 + aminopropyl). Excellent recoveries (92.6 – 108.7%) and relative standard deviations (< 10%) were obtained for the 22 steroids evaluated.
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Gingerol Purification with Centrifugal Partition Chromatography SCPC-250
Gingerol, a naturally occurring plant phenol, is one of the major components of ginger and is responsible of the characteristic taste of ginger. Centrifugal partition chromatography (CPC) also known as counter current chromatography (CCC) is a preparative, pilot, and industrial liquid purification technique that does not require traditional solid supports. CPC was used to purify few mg of gingerol from crude extract.
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