LCGC Europe Application Note Alert
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October 2015
HPLC
GPC
 

Featured Application Note:

Solid-Phase Extraction for the Analysis of Drugs of Abuse in Urine
Many drugs of abuse (DOA) — whether natural or synthetic — are rapidly excreted from the human body. However, some can persist for extended periods. Screening for traces of DOAs has become commonplace by analyzing human urine with liquid chromatography–mass spectrometry (LC–MS) or gas chromatography–mass spectrometry (GC–MS) through derivitization of the parent compounds. Solid-phase extraction (SPE) provides an ideal extraction media for DOA compounds, as it can be performed with small sample amounts with rapid turnaround.
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HPLC
Usability Study of a New HPLC, a New Tandem MS and a New Data Processing Software
This usability study evaluated a new two-channel HPLC system, a new tandem MS and data processing software for general clinical use, focusing on the areas of stability, robustness and time efficiency.
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Achieving the Shortest Run Time and Narrowest Peak Shape in UHPLC
This technical overview describes how to achieve the shortest run time and narrowest peak shape using the Agilent 1290 Infinity II LC with ultralow dispersion kit.
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Separation of Pharmaceutical Metabolites with HPLC
Fortis Technologies Limited has designed its Diphenyl stationary phase to provide selectivity of difficult to resolve metabolites such as positional isomers. Small changes in the chemical functionality of a drug are quite often subtle, leading to a complexicity in achieving separation. In this application note we highlight how a unique selectivity stationary phase, Fortis Diphenyl, can aid in the simple separation of these closely related species. Maintaining good chromatography of these metabolites leads to good qualitative and quantitative accuracy.
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Detection of Aflatoxins in Milk at Picogram Levels Using SPE and LC–MS–MS
A simple and effective method using polymeric solid-phase extaction (SPE) and liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) is presented for the analysis of aflatoxins in milk at the low concentrations required.
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Sample Prep
Multiresidue Analysis of Pesticides in Avocado with Agilent Bond Elut EMR—Lipid by GC–MS–MS
This note features Enhanced Matrix Removal—Lipid, a next generation of sample preparation product, used for highly selective matrix removal without impacting analyte recovery, improving accuracy and reliability of results.
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Rapid Chlorinated Pesticides Extraction and Analysis from Poultry Fat (SPE–GC)
Pesticide contamination is not limited to produce items. Animals used for food consumption are also exposed to contaminants at levels that can be harmful to the human population. A method has been developed using SPE and GC–ECD for pesticide analysis from poultry fat. This method improves upon the traditional procedure resulting in a 75% reduction in laboratory space, a reduction of hazardous waste, and a 50% reduction in labour consumption, leading to greater laboratory productivity.
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GPC
Absolute Molar Mass in UHPLC via the µDAWN and UT-rEX
Ultrahigh-performance liquid chromatography (UHPLC) enables fast, efficient separation of biomolecular samples. Compared to standard SEC, UHPLC–SEC provides improved resolution, higher throughput, less solvent, and smaller sample consumption for analysis of precious biological samples.
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How to Maximize Absolute Molecular Weight Measurement Accuracy: Synthetic Polymers
The molecular weight, molecular weight distribution, and molecular size of three common polymers are measured using OMNISEC. This information can provide insight into the physical properties and behaviour of these synthetic polymers.
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