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The Analysis of Chlorinated Dioxins, Difurans, and Polychlorinated Biphenyls in Edible Oils
The dioxin family consists of 210 compounds, of which 17 contain the 2,3,7,8 pattern of chlorination. These 2,3,7,8-containing compounds are of extreme concern to human health because of their high level of toxicity. Approximately, 12 of the 209 polychlorinated biphenyls have also been identified as human toxins. For this reason, the US FDA and EU have established strict regulations for the monitoring of food products for human consumption, in particular edible oils. Manual extractions of oils can be a time-consuming procedure often delaying lab turnaround times. By automating the process with the PowerPrep®, food oil samples can be reliably processed with routine 24 h turnaround times.
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Determination of 35 Pesticides and Three Cannabinoids in Marijuana Edibles
As of July 2015 within the US, 23 states and Washington D.C. have legalized the medical use of marijuana, while 4 states and Washington D.C. have legalized the recreational use of marijuana. As a result, many forensic toxicology laboratories are looking for fast, reliable, and cost-effective methods to determine cannabis potency and pesticides in edibles. This application utilizes the advantages of QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) to extract 35 pesticides and three cannabinoids including tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN) in edibles, followed by either serial dilutions for cannabis potency analysis, or a dispersive solid-phase extraction (dSPE) cleanup for pesticide residue analysis. This hybrid method allows the QuEChERs technique, which is extensively used in the food testing industry, to be utilized in a forensic setting.
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Extraction of Opioid Derivatives Using Evolute Express CX
This application note describes an extraction method for buprenorphine and norbuprenorphine from oral fluid using Evolute Express CX prior to LC–MS–MS analysis. Evolute Express products combine powerful “Evolute” sorbent chemistry with enhanced “Express” components. There is no need for conditioning and equilibration; just simply load, wash, and elute.
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Mass-Directed Isolation of a Synthetic Peptide Using the ACQUITY QDa Detector
This application note illustrates a simple mass-directed approach to peptide isolation and discusses the options for improving the efficiency of the purification protocol.
• Isolation is easily accomplished using the ACQUITY QDa Mass Detector as configured in the Waters AutoPurification System, making it a lower cost alternative for purification of those peptides with mono-isotopic masses or multiple charges that fall within the 30–1250 Da mass range of the detector.
• Columns with different selectivity are sometimes necessary for improving the separation of crude sample mixtures, which ultimately leads to the isolation of higher purity target peptides.
• Focusing the gradient improves the resolution of closely-eluting or co-eluting peptide impurities, contributing to the ease of target peptide isolation.
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