LCGC Europe Application Note Alert
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December 2015
GPC
HPLC
 

Featured Application Note:

Blood Alcohol Content Analysis Using Nitrogen Carrier Gas
Alcohol consumption can seriously affect the ability of a driver to operate a vehicle and blood alcohol content (BAC) directly correlates with this impairment. Here we compare the analysis of real forensic blood samples, taken from motorists suspected of driving under the influence of alcohol, and analyzed using nitrogen and helium carrier gas.
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Sample Prep
Analyzing Infant Formula for Dioxins and Furans Using Pressurized Liquid Extraction and Automated Sample Clean Up
Because of important public health considerations for children, infant formula has been tested for persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins (PCDDs) and furans (PCDFs). Typically, concentrations of these analytes found are lower than in human breast milk but continuous monitoring is important. This requires well equipped laboratories capable of trace-level analysis work, because PCDD/Fs amounts are often at the picogram or femtogram level. Automation reduces time, labour solvent, and error.
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PAH Analysis in Salmon with Enhanced Matrix Removal—Lipid
This note features Enhanced Matrix Removal—Lipid, a next generation of sample preparation product, used for highly selective matrix removal without impacting analyte recovery, improving accuracy and reliability of results.
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GPC
Absolute Molar Mass in UHPLC via the µDAWN and UT-rEX
Ultrahigh-performance liquid chromatography (UHPLC) enables fast, efficient separation of biomolecular samples. Compared to standard SEC, UHPLC–SEC provides improved resolution, higher throughput, less solvent, and smaller sample consumption for analysis of precious biological samples.
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Structural Elucidation of Dextrans and Other Polysaccharides Using Multi-Detection GPC/SEC
A series of dextran samples ranging in molecular weight from about 1–650 kDa are characterized using the OMNISEC GPC/SEC system. Structural comparisons to other polysaccharides, gum arabic, and pectin are presented.
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HPLC
Automated Scouting of Stationary and Mobile Phases
This technical overview demonstrates the use of the Agilent 1290 Infinity II Method Development Solution for automated scouting of stationary and mobile phases.
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Detection of Aflatoxins in Milk at Picogram Levels Using SPE and LC–MS–MS
A simple and effective method using polymeric solid-phase extaction (SPE) and liquid chromatography coupled to tandem mass spectrometry (LC–MS–MS) is presented for the analysis of aflatoxins in milk at the low concentrations required.
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Sensitive Analysis of the Lactose Content of Lactose-Free Labelled Products Using HPAEC-PAD
An HPLC method that easily reaches the required LOD by using high-performance anion-exchange chromatography coupled to pulsed amperometric detection (HPAEC-PAD) on a KNAUER AZURA® Analytical HPLC system coupled to the DECADE II electrochemical detector is presented. The selective method can differentiate several sugars.
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Separation of Free Amino Acids and Primary Amines Using Daicel Crown Ether Columns
A new generation of Daicel CROWNPAK® chiral selectors, CROWNPAK CR-I(+) and CROWNPAK CR-I(-) can be used for the separation of free amino acids and primary amines. Recent scientific studies have demonstrated that the brain of Alzheimer’s disease patients contains unusually high levels of D-serine. This note describes the use of CROWNPAK CR-I(+) to develop the separation of DL-serine.
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Dimethylamine in Meropenem using IC
Meropenem is known as a carbapenem-type antibiotic that works by inhibiting the cell wall synthesis of bacteria. In its synthesis, dimethylamine is used as a precursor for which reason it also occurs as an impurity in the final product. It is sensitively and accurately determined via ion chromatography with conductivity detection.
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