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LCGC Europe - News Bulletin
 
15 October 2015

LCGC TV: Robert T. Kennedy, Part 3: Derivatization to the Rescue
In this video, Robert T. Kennedy of the University of Michigan discusses how derivatization can improve method sensitivity and speed in a study on chemical in vivo neuromonitoring using liquid chromatography–mass chromatography (LC–MS).
An Economical and Green approach for the Total Analysis of Dioxins, PCBs and PBDEs.
Several recent advances in New Automated Sample Prep Systems and Chemistries have been made. These advances have greatly reduced the costs and solvent consumption associated with the analysis of Dioxins, PCBs and PBDEs delivering consistent, high recoveries for the analysis in the same day. Register to attend a Webinar November 18th to learn more about recent advances in Sample Prep systems and Chemistries.
The LCGC Blog: Simple Visual Methods to Assess HPLC Column Performance – And Get You Out of Trouble!
LCGC blogger Tony Taylor offers some simple visual methods to assess column performance.
 
LC Column Problems Everywhere
No matter where you live or whom you work for, you’re likely to encounter one or more of these liquid chromatography (LC) column problems at some point. John Dolan explains more.

Photo Credit: ALFRED PASIEKA/SCIENCE PHOTO LIBRARY/Getty Images
Three-Dimensional Thinking: 3D Printing in Separation Science
Brett Paull from ACROSS — Australian Centre for Research on Separation Science, School of Physical Sciences, University of Tasmania, Hobart, Australia, spoke to The Column about the possibilities for 3D printing in the separation science sector.
LCGC E-Book: Advancing Biopharma Analysis with Light-Scattering Detection
To characterize biopharmaceuticals, particularly monoclonal antibodies and antibody–drug conjugates (ADCs), you need a complete toolbox of powerful tools. You are probably familiar with LC–MS methods. But have you seen what light-scattering detection can do? Click to Download E-Book

Photo Credit: MOLEKUUL/SCIENCE PHOTO LIBRARY/Getty Images
News: High-Throughput Screening of Heparin Using LC–MS
A new study published in the journal Analytical Chemistry presents a screening strategy using hydrogen peroxide digestion followed by fast reversed-phase ion pairing liquid chromatography (reversed-phase IP–LC) coupled with tandem mass spectrometry (MS–MS) to detect contamination of heparin samples.
Million Metabolome Project, an ambitious milestone for Exposome Research
Ultra high resolution, accurate mass (UHRAM) mass spectrometry, based on the Thermo Scientific™ Orbitrap™ technology, is a powerful new approach to high throughput screening and quantitation in complex sample matrices. To learn more about how UHRAM is used in the Million Metabolome Project, an ambitious milestone for Exposome Research, LCGC talked with Dean Jones of Emory University.
>> Access the podcast

>> View the whitepaper
Technical Tip: Static Headspace Sampling
Static headspace sampling is typically used for the determination of volatile and semi-volatile analytes in liquids and, more rarely, solid matrices. Application examples include the analysis of alcohols in blood, residual solvents in pharmaceuticals, flavours and taints in food and beverages as well as fragrances in perfumes and detergents.
Featured Products
New OMNISEC GPC/SEC System TSKgel Size Exclusion Columns for UHPLC
For absolute molecular weight characterization of synthetic and natural polymers, as well as determination of aggregation and oligomeric state of proteins with the lowest of sample concentration requirements. Learn more TSKgel UP-SW3000 columns packed with 2 µm silica based particles are the latest addition to the popular TSKgel SW series, the gold standard for QC analysis of antibody therapeutics. The new silica-based UHPLC columns are based on the proven proprietary surface technology of the TSKgel SW family and are ideally suited to facilitate the transfer of existing HPLC methods to UHPLC systems.
Read more

Flexible Ultrapure Water SpeedCore HPLC range
PURELAB® flex combines ease of use with the accurate delivery of pure water. The flexible modular system can be configured to deliver the quality of water you need for your applications. Learn more Fortis SpeedCore  HPLC columns now come in Diphenyl, PFP and HILIC options to compliment the C18 chemistry already available.  This provides increased selectivity to supplement the high efficiency of the Speedcore particles, resulting in higher resolution separations. Learn more
 
Upcoming Webcasts

Overview of Hydrophilic Interaction Chromatography (HILIC)
Tuesday, October 20, 2015
2:00—3:00 pm EDT

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Column Thermostatting—Understanding an Underestimated Parameter to Improve Efficiency and Selectivity in UHPLC
Thursday, October 22, 2015
8:00 am PDT/ 11:00 am EDT/ 4:00 pm BST/ 5:00 pm CEST

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Understanding the Impact of System Dispersion on Separation Performance
Tuesday, October 27, 2015
8 am EDT/ 11 am EDT/ 3 pm GMT/ 4 pm CET

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Streamlining Routine Workflows in the Environmental Laboratory
Wednesday, October 28, 2015
11 am EDT/ 8 am PDT/ 3 pm GMT/ 4 pm CET

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5 Secrets of Detailed Polymer Characterization and Deformulation
Thursday, October 29, 2015
11 am EDT/ 10 am PDT/ 8 am PDT

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On Demand Webcasts
Streamlining Routine Workflows in the Environmental Laboratory, Part I
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Accelerating HPLC/UHPLC Method Development Strategies by Leveraging Selectivity: Influence of Unique C18-Based Stationary Phases
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The Utilization of LC–MS–MS in Development of Solid-Phase Extraction Methods
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Unravelling the Structure of a Monoclonal Antibody: A Targeted Bottom-Up and Top-Down
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