LCGC Blog
Our technical support center deals with many issues regarding irreproducibility of retention and selectivity in reversed phase HPLC. Very often, the problem lies in poor equilibration of the HPLC column between injection, which in gradient HPLC can affect the separation selectivity as well as analyte retention. Read more
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LCGC TV
In the latest clip from LCGC TV, Gene Barry from the University of Massachusetts Lowell discusses the three approaches that can help to bring a column back to life. Read more
NEWS
Researchers have investigated the use of size-exclusion chromatography (SEC) for size distribution analysis of influenza virus particles. Read more
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FEATURED ARTICLES
This review discusses the different analytical strategies that can be adopted to overcome (or at least reduce) the sample preparation difficulties encountered when chromatographic techniques are involved for final instrumental determination. Read more
Ion chromatography coupled to mass spectrometry (IC-MS) does not follow the same rules as coupling other modes of liquid chromatography to mass spectrometry (LC–MS). Leon Barron from the Analytical & Environmental Science Division, at King's College London, UK, reveals some of the misconceptions surrounding IC and discusses contemporary trends and novel applications for this inventive technique. Read more
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Application Notes
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This application highlights the 50-fold scale up of a mixture of four aromatic compounds from analytical to semi-preparative chromatography. The Gilson PLC 2050 Purification System performs reproducible and highly efficient analytical to semi preparative injections providing scientists with the flexibility to quickly and easily scale up from 4.6 mm to 25 mm ID columns.
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This application note describes HPLC method transfer to UHPLC for the analysis of lipid soluble antioxidants using an ACQUITY Arc System and a 2.7 ìm CORTECS T3 Column. This method transfer results in better resolution with reduced sample run time and solvent consumption.
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FEATURED PRODUCT
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MethodsNow™ features step-by-step instructions for analytical and synthetic methods in areas like pharmacology, HPLC, food analysis, natural product isolation analysis and water analysis.
 Click here to learn more
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