The LCGC Blog
I believe that the term "top-down proteomics" holds a particular connotation with respect to the use of ultrahigh-resolution mass spectrometers in people's minds. And rightfully so. If one is to determine with confidence the sequence and charge state of a particular fragment ion generated in the gas phase, then high mass accuracy is a must. Read more
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Perspectives in Modern HPLC
This instalment of "Perspectives in Modern HPLC" highlights historical perspectives on the development of ultrahigh-pressure liquid chromatography (UHPLC) into a modern high performance liquid chromatography (HPLC) platform and describes the important instrumental features common to most commercial equipment. Read more
LCGC TV
Susan Olesik from The Ohio State University talks about the role of green chemistry in industry and how the movement is very much alive and well. Read more
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Feature
High quality, low cost is a standard mantra within the pharmaceutical industry, but with increasing structural complexity of drugs and drug candidates maintaining the core value of this mantra is becoming more difficult. Kanta Horie from Eisai Co., Ltd., recently spoke to The Column about the development of an intelligent peak deconvolution technique using multivariate curve resolution-alternating least squares (MCR-ALS) that allows accurate quantitation of multiple components with different absorbing spectra, even if the peaks are not completely separated. Read more
News
Researchers from Zhejiang University, China, have created a graphene-coated polymeric stationary phase and demonstrated its performance separating inorganic anions, organic acids, carbohydrates, and amino acids using anion exchange chromatography. Read more
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