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LCGC Blog
As I've written previously, our Nirvana in HPLC column selection would be to enter the structures of our analytes and have a database tell us the column and mobile phase conditions that we should use to carry out the separation successfully. Although I know of several groups who are working on this, in practice we are still a long way from realizing this goal. read more
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Featured Article
This article will demonstrate how a simple test mixture of carefully selected compounds can facilitate both the development of generic ultrahigh-pressure liquid chromatography–mass spectrometry (UHPLC–MS) methods and automated performance monitoring of multiple instruments located in separate laboratories and buildings. read more
LCGC TV
There has been an increase in interest in hydrophobic interaction chromatography (HIC) for protein separations. Alain Beck from the Center of Immunology Pierre Fabre discusses his proposed workflow for the separation of monoclonal antibodies and antibody-drug conjugates. read more
HPLC Previews
This is the second in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2017 conference in Prague, Czech Republic, from 18–22 June.
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News
Few fruits are as notorious as the Durian fruit. Native to Southeast Asia but fast becoming available around the globe, these fruits hold the unsavoury title of "the world's smelliest fruit". The compounds responsible for such a complex and at times difficult to stomach aroma have intrigued scientists for decades, but until recently the data relating to those chemicals was inconsistent. To address these inconsistencies, researchers from Deutsche Forschungsanstalt für Lebensmittelchemie investigated the fruit using GC–O, AEDA, and stable isotope dilution assays to establish the key compounds responsible for the odour. read more
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Application Note
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Benzodiazepines are recurrently used as illegal recreational drugs. Similar to other commonly abused compounds, such as cannabinoids or amphetamines, "legal" alternatives have been developed for ...  Read more |
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