HPLC 2017 Topic Preview

The Rising Profile of Comprehensive LCxLC

This is the fourth in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2017 conference in Prague, Czech Republic, from 18–22 June. Peter Schoenmakers from the University of Amsterdam, The Netherlands, previews the rising profile of comprehensive 2D LC, a technique that some members of the separation science community are still not convinced has value. read more

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LCGC Blog

The LCGC Blog: Ghost Peaks in Gradient HPLC

I guess we have all had the issue at some time or other. A blank injection of eluent (or a zero volume dummy injection) gives rise to discreet peaks on the chromatographic baseline which may interfere with analyte peaks or increase the complexity of the chromatogram obtained, especially when performing trace analysis. read more

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Features

Characterizing Monoclonal Antibodies and Antibody–Drug Conjugates Using 2D-LC–MS

Two-dimensional liquid chromatography (2D-LC) has in recent years seen an enormous evolution, and with the introduction of commercial instrumentation, the technique is no longer considered a specialist tool. One of the fields where 2D-LC is being widely adopted is in the analysis of biopharmaceuticals, including monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs). Using practical examples from the authors' laboratory complemented with background literature, the possibilities of on-line 2D-LC for the characterization of mAbs and ADCs are presented and discussed. read more

Application Note

Determination of Olefin Content in Denatured Ethanol According to ASTM D7347

This Application Note demonstrates the determination of the olefin content in denatured ethanol using the Agilent 1260 Infinity Analytical SFC system with the SIM Flame Ionization Detector (FID). Read more