The LCGC BLOG
Internal standards (IS) are commonly incorporated into quantitative methods to increase accuracy and precision. An IS is a compound that is different than the analyte of interest, has similar physicochemical properties to the analyte, and is added to samples, calibration standards, and quality control samples in a known quantity. It should not be present in the sample, it should be available in high purity, and it should be easily differentiable from the analyte of interest. read more
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Traditional techniques used to perform the extraction of pesticides from food matrices are time consuming, solvent intensive and can deliver inconsistent results. The need for economical, fast, reproducible testing protocols exists. Perform consistent extraction of pesticides for analytical quantitation in 10 minutes. The PLE can dramatically improve reproduciblity of results, speed and cost of extractions.
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LCGC TV
Peter Schoenmakers from the University of Amsterdam discusses what he found when he compared the potential peak capacities of two and three-dimensional LC. He also reviews how he approaches orthogonality in a 3D LC separation. read more
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Please share your thoughts on flow splitting applications in LC-MS and HPLC in this simple market research survey that will only take a few minutes to complete.  CLICK HERE
NEWS
Researchers from ANSES have investigated the human health risks related to the consumption of foodstuffs produced on sites polluted by munitions from the First World War using GC–MS, HPLC–ICP-MS, and UHPLC–MS. read more
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View the growing list of zwitterionic, HILIC column applications from The Nest Group™. The list describes  separations of lipids and phospholipids by head group. Included literature references provide an overview of the capabilities of these silica and polymer based HILIC chemistries. Try iHILIC® Fusion columns or SPE cartridges today! The Nest Group, Inc. - “Not Just Columns ... Answers!”
PERSPECTIVES IN MODERN HPLC
This instalment in our series on ultrahigh-pressure liquid chromatography (UHPLC) highlights its benefits in fast analysis, high-resolution separations, high performance liquid chromatography (HPLC) method development, reduced solvent and sample usage, and enhanced sensitivity and precision performance. read more
FEATURE
Mixed-mode high performance liquid chromatography (MM-HPLC) involves the combined use of two (or more) retention mechanisms in a single chromatographic system. In this review, the authors discuss mixed-mode chromatography stationary phases. An overview of applications using mixed-mode chromatography is described, as well as the increased interest in mixed-mode systems for two-dimensional chromatography. read more
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