The LCGC Blog
If given the need to determine drug A or its metabolite in blood, 99% of the time I would choose to start with liquid chromatography–mass spectrometry (LC–MS).
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Features
Monitoring oxidation in biopharmaceuticals using top-to-bottom HPLC methods is demonstrated in this LCGC "Biopharmaceutical Perspectives" instalment.
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A robust approach to analyzing glycols in aqueous samples, which reduces downtime and maintains sensitivity, is described.
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News
Researchers from the Université de Pau et des Pays de l'Adour, in France, have developed a large volume injection method using a programmed temperature vaporization (PTV) injector for the simultaneous determination of mercury, tin, and lead at ultra-trace levels in natural waters using GC–ICP-MS.
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LCGC spoke to Andrew Turner, Principal Chemist in the Food Safety Group at the Centre for Environment, Fisheries, and Aquaculture Science (Cefas) in Weymouth, UK, about developing a simple ultrahigh-pressure liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) method for the quantitation of microcystins and nodularin in various sample matrices.
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Application Note
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Ten classes of phospholipids were analyzed by HILIC–MS/MS using an iHILIC®-Fusion column. The applicability of the method for potential clinical application is shown.  Read more
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Upcoming Webcasts
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