October 11, 2018

LCGC Europe Weekly Update
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October 11, 2018

LCGC Blog

The LCGC Blog: Improve Sensitivity and Reproducibility Using Pulsed Pressure Splitless GC Injection

In my previous blog, I discussed the possibility of backflash in splitless GC injection and its effect on quantitative reproducibility and carry-over. While much is written in the literature on optimization of splitless injection conditions, little is available on the implementation and optimization of increased head pressure (pressure pulsed) injection, so we will concentrate on this aspect of injection optimization. Read more

More of What You Need to Keep Your LC Flowing

Restek has expanded our line of LC accessories to bring you even more of what you need to keep your LC flowing. Browse top-quality couplers, fittings, unions, tees, and crosses; PEEK and stainless steel tubing; mobile phase maintenance and safety products including bottle tops, valves, filters, and spargers—and that's on top of our already wide selection of instrument replacement parts and supplies. Don't stop at the column; outfit your entire LC system with Restek LC products. Learn more

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Features

Tips, Tricks, and Troubleshooting for Separations of Biomolecules, Part 2: Contemporary Separations of Proteins by Size-Exclusion Chromatography

Several new materials and columns have been introduced in recent years for size-exclusion separations of proteins. How do I know which one to choose, and which separation conditions will be the best for my protein separation? Learn more

Data Integrity and USP <1058>, Part 2: OQ Supervision and Execution

This is the second of three articles looking at the impact of the new USP <1058> on AIQ on data integrity in a regulated chromatography laboratory and focuses on how the laboratory should supervise the execution of OQ protocols by a third-party service provider. Learn more

Versatile and Automated Mass Spectrometry-Based Approaches for Monoclonal Analysis

The molecular complexity of monoclonal antibodies (mAbs) makes accurate characterization challenging. This ebook highlights versatile and automated mass spectrometry-based approaches for intact protein analysis, peptide mapping, and glycan analysis that deliver quick and reliable answers. Download the eBook

News

Retroactive Toxicology Study on Adolescents Using GC–MS

Toxicological surveillance of illicit prescription and illegal drug abuse has been carried out using post-mortem data from Clark Country, Nevada, USA, with GC–MS, headspace GC–MS, GC×GC–MS, LC–MS, and ELISA. Read more

Application Note

Analysis of Oligonucleotides with Online Desalting

This application note shows the 2D-LC analysis of oligonucleotides in solution with high salt content. The 2D-LC method enabled a threefold increase in workflow speed. / Learn more /

FEATURED PRODUCTs

Safety Exhaust Filters

When filling a waste bottle or waste canister, volatile organic compounds are forced out of the vessel. Because it is a waste solution, often not much care is taken and the volatile compounds pollute the air in the lab. With this new VICI Exhaust filters toxic fumes from waste vessels can be prevented from contaminating the air in the working environment. www.vici-jour.com
VICI AG International, Schenkon, Switzerland / Learn more /

GPC Cleanup system for automated sample preparation

This system automates sample preparation based on gel permeation chromatography (GPC). It automatically processes up to 15 samples on minimal bench space. Based on the AZURA® device platform, the system is customizeable to fulfill individual requirements. Contact info: KNAUER Wissenschaftliche Geräte GmbH Hegauer Weg 38, 14163 Berlin, Germany
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www.knauer.net, info@knauer.net / Learn more /

Analysis of Phospholipids with iHILIC®-Fusion

HILICON HILIC columns, iHILIC®-Fusion, iHILIC®-Fusion(+), and iHILIC®-Fusion(P), are versatile for the LC–MS analysis of polar compounds in "Omics" researches, pharmaceutical discovery, and clinical diagnostics. A recent application shows 10 phospholipids (PLs) classes can be well separated by an iHILIC®-Fusion column. The method is applicable for the potential clinical applications. / Learn more /

Automation of Analytical Sample Preparation.

A desktop instrument, ePrep allows robotic sample preparation of analytical sample batches with effortless accuracy and consistent results. It targets Environmental, Clinical, Food, Life Sciences, Biotechnology and Forensics markets against alternative technologies and competitors. / Learn More /

Preperative Column Selfpacking

Pack your own Spring® columns from 25mm to 70 mm ID with very high performance and reproducibility. The packer has a high safety standard, and can be used in explosion-hazard areas. / www.MODcol.com /
Dr. Maisch HPLC GmbH

Automated SPE system

The GERSTEL SPE 2 processes samples using individual 1, 3, and 6 mL SPE cartridges for easy automation of manual SPE methods in combination with GC/MS or LC/MS. / Learn More /

Bal Seal® for HPLC, UHPLC Pumps

The Bal Seal® combines advanced polymers with a wear-reducing spring energizer to dramatically reduce contamination, improve sample accuracy, boost throughput, and prolong service life. It helps pump designers meet demanding PM requirements of >1M cycles/60L. / Learn More /