LCGC Blog

A Decision Tree for Gas Chromatography Method Development

To answer the question "Is there a good flow diagram I can use for GC method development?" please see below for our first attempt at something suitable, in the form of stepwise decision trees and flow diagrams.  Read more

Features

Hydrophilic Interaction Liquid Chromatography: An Update

This article is an update on the technique of HILIC and covers recent ideas on the mechanism of separation, and how it may be manipulated to suit the separation of particular sample types. The advantages of HILIC are discussed, and also the actual and perceived disadvantages of the technique. Read more

Recent Advances in Solid-Phase Microextraction, Part 1: New Tricks for an Old Dog

Solid-phase microextraction (SPME) was introduced nearly 30 years ago and since that time has matured into a widely used tool in the arsenal of sample preparation techniques. Simultaneously, it has spawned a host of related techniques where sorbent coatings are placed on stir bars, magnetic particles, vial walls, and so on. Over the past few years, several advances in SPME have been developed, including increasing the sorbent surface area available for extraction, accommodating direct analysis by mass spectrometry (MS), and sorbent overcoating to resist fouling by sugars, lipids, and other macromolecules present in some sample types. These advances are discussed in this month’s instalment. The use of SPME for microsampling of biological systems, so-called bio-SPME, will be the focus of Part 2. Read more

News

Investigating the Effect of Kynurenic Acid in Alcoholic Beverages

Researchers from the Medical University of Lublin, Poland, have investigated the presence of kynurenic acid in alcoholic beverages and the significance of its presence using high performance liquid chromatography. Read more