May 03, 2019

LCGC Europe Weekly Update
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MAY 03, 2019

LCGC Blog

Commercial Sample Preparation Materials for Isolation of Intact Proteins from Biological Samples are Absent in the Marketplace

We have been working to develop the use of liquid chromatography–triple quadrupole–mass spectrometry (LC–MS/MS) for quantification of intact proteins from biological fluids.
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Features

Middle-Up Characterization of the Monoclonal Antibody Infliximab by Capillary Zone Electrophoresis–Mass Spectrometry

The potential of CZE–MS for the middle-up characterization of mAbs is highlighted. Read more

New Liquid Chromatography Columns and Accessories for 2019

Our annual review of new liquid chromatography columns and accessories, introduced at Pittcon and other events. Read more

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Hot Topics Preview: A Universal Generic (U)HPLC Reversed-Phase Gradient Method for Quality Assessments of Multiple Small Molecule Drug

This is the third in a series of articles exploring current topics in separation science that will be addressed at the HPLC 2019 conference in Milan, Italy, from 16–20 June. Read more

News

Investigating Mycobacteria FAME Profiles Using Alternative Ionization Energies in GC–MS

Researchers have investigated alternative ionization energies for the analysis of volatile and semivolatile compounds using gas chromatography coupled with electron ionization mass spectrometry (GC–EI-MS). Read more

FEATURED PRODUCTS

Sub-2 micron chiral columns

Daicel now offers a full set of columns packed with sub-2 micron chiral stationary phases: CHIRALPAK® IA, IB, IC, ID, IG, and IH. This full set offers ultrafast separations, higher resolution power, and results in seconds. /Learn more/

Compliant GPC/SEC/GFC Software

WinGPC software for GPC/SEC, IPC and 2D-LC enables compliance with FDA21CFR11 also for (multi angle) light scattering. WinGPC can control different LC systems and load CDS data (e.g. Chromeleon™ 7.2). /Learn more/

A powerful new tool for the separation of charged species

The Postnova EAF2000 instrument using Electrical Asymmetrical Flow Field-Flow Fractionation (EAF₄) technology allows the particle size or molar mass distributions to be further differentiated and transformed into charge distributions. /Learn more/

New Direct-Connect 360µm Fittings

Our new fitting connects a 360 µm FS tube directly into a 1/16" fitting detail, with the bore of the FS tube precisely aligning with the bore of the valve. /Learn more/

Application Notes

EU-WFD contaminants by SBSE-GC-MS/MS

Solvent-reduced determination of 100 contaminants from low double-digit to low triple-digit pg/L in 100 mL surface water samples, meeting the requirements of the EU-WFD based on SBSE-TD-GC-MS/MS. /Learn more/

Mass-Based Isolation of Natural Product Impurities

This application note describes the isolation of a natural product extract. Mass-selective detection was used to trigger collection of the desired compounds. /Learn more/

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