LCGC Blog

Exosomes – A New Frontier in Cancer Biomarker Discovery and Quantitation

Exosomes are small lipid membrane-bound extracellular vesicles, on the order 30–150 nm in diameter, which are shed by normal and tumor cells in the body. They are circulating within your body and can be isolated from virtually any biological fluid. Exosomes released from tumor cells have been shown to be enriched in certain proteins. These nanobodies hold significant promise for the discovery of cancer biomarkers, for cancer diagnosis and prognosis, and for biomarker quantitation.
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Native–MS Protein–Ligand Affinity
Native MS monitors the molecular mass of protein complexes under non-denaturing conditions. It can provide key insight into the identity of bound ligands, the stoichiometry of protein-ligand binding and even strength of binding. Use a Native-MS QTOF system as a starting point in drug discovery research where libraries of small molecule fragments (potential drugs) are screened to identify fragments that bind with a protein or ribosome target. Try our solution-based, affinity selection, coupled column SEC-RPC or SEC-Native MS assay techniques today! LEARN MORE at The Nest Group, Inc. – "Not Just Columns ... Answers!"

Features

Reversed-Phase Liquid Chromatography and Water, Part 1—How Much is Too Much?

When can we use completely aqueous eluents with reversed-phase stationary phases, and what happens if we make a mistake? Read more

VICI UHPLC Fingertight Fittings
VICI Jour fingertight fittings easily connect the components of (U)HPLC systems, available in different colors, lengths, and shapes to fit any customer needs. Learn more

New Sample Preparation Products and Accessories

This yearly report on new products introduced since March 2018 covers sample preparation instruments, supplies, and accessories. Read more

ISPPP 2019
Check out the conference of the year on Separation, Purification and Characterization Methods related to Biologically Important Molecules! Program will address key developments and applications, productivity and financial challenges, and novel approaches related to biological molecule separations and analysis, critical in clinical and biopharmaceutical research and are requirements in manufacturing and quality control of new biotherapies and diagnostics. ISPPP.org July 10–12, 2019, Baltimore MD USA