Articles

High-throughput Multiplexing Gas Chromatography
Oliver Trapp
A novel way to radically improve the throughput of GC systems is described. This approach increases the amount of chromatographic information that can be obtained in one run as well as decreasing the overall analysis time.

On-line Whole Blood Analysis using Microextraction by Packed Syringe (MEPS) and LC–MS–MS
Mohamed Abdel-Rahim
Microextraction by packed syringe (MEPS) is a sample preparation technique that can be connected on-line with liquid chromatography (LC) or gas chromatography (GC) without any modifications. A method of quantifying different drugs in whole blood samples is described.

Columns

LC TROUBLESHOOTING
Selectivity in Reversed-Phase HPLC Separations (Part 4): Pressure Selectivity
John Dolan
The role that pressure plays in selectivity in RP-HPLC.

QUESTIONS OF QUALITY
Is GMP Annex 11 Europe's Answer to 21 CFR 11.
Bob McDowall
New EU legislation on computerized systems will affect chromatography laboratories. Are you properly prepared?

PRACTICAL DATA HANDLING
Problems with Optimization in Pharmaceutical Analysis
Yvan Vander Heyden
Experimental design or sequential approaches can be used to optimize separations involving drug-impurities. This article looks the different stages of an experimental design-based approach and the problems that can arise from inappropriate choices.

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