Application Note Alert
February 2011 Subscribe
Links to technical insights from sponsored Featured Application Notes on Chromatography Online.
Contact Editor
- Janet Kelsey

Featured Application Note:
Analysis of Triazine Herbicides in Drinking Water Using LC-MS/MS
By Jonathan R. Beck, Jamie K. Humphries, Louis Maljers, Kristi Akervik, Charles Yang, Dipankar Ghosh, Thermo Fisher Scientific
Learn about an easy LC-MS/MS method used to analyze triazines in large volumes of drinking water. The method described saves considerable time and expense compared to traditional solid phase extraction (SPE) techniques.
LC/HPLC
Automated One Step Solid Phase Extraction and Concentration of PCBs In Drinking Water
Phillip Bassignani, FMS, Inc.

PCBs are a group of synthetic organic chemicals that contain 209 individual compounds (known as congeners) with varying harmful effects. PCBs enter the environment as mixtures containing a variety of individual components. Seven types of PCB mixtures include 35% of all the PCBs commercially produced and 98% of PCBs sold throughout the world.
Evaluation of Newer Technologies for the LC/MS/MS Analysis of Amphetamines using Strata™-X-Drug B Solid Phase Extraction (SPE) and Kinetex® Core-Shell HPLC/UHPLC Columns
Michael Rummel, Matthew Trass, and Jeff Layne, Phenomenex

This study evaluates the performance of four different HPLC columns used to analyze amphetamines, a commonly tested drug class and demonstrates an improved analysis speed when coupling a simplified and effective SPE procedure with a core-shell HPLC column and LC/MS/MS detection.
Sample Prep
Confirmation and Quantitation of Cocaine and Major Metabolites
Matthew Lambing, Eric Phillips, Trisa Robarge, Thermo Fisher Scientific

A method was developed to demonstrate the performance of the Thermo Scientific ISQ GC-MS system for the confirmation and quantification of cocaine and its major metabolites in a urine matrix. The methodology offers excellent precision and the assay described provides a broad linearity to cover a wide range of analyte concentrations, reducing the need for dilutions or repeat extractions.
Sample Prep
Determination of Haloacetic Acids in Drinking Water by IC/MS/MS
Stacy Tremintin, AB SCIEX

This tech note describes a IC-MS/MS method that follows the current guidelines outlined in EPA Method 557, and was found to be sensitive and reproducible for the quantitation of low-level haloacetic acids, bromate, and dalapon in drinking and surface waters.
Analysis of Chlorinated Herbicides in Water with Online Enrichment
Srividya Kailasam, Agilent Technologies

The analysis of eight chlorinated herbicides in 1.8 mL of acidified water by online enrichment using highly efficient sub-2-µm trace enrichment and analysis columns fitted on Agilent 1260 Infinity LC system is described.
UPLC® and Online Radioactivity Detection of Metabolites
Filip Cuyckens, Carine Borgmans, Marc Bockx, Rainer Kembuegler, Hans Van Malderen, Davy Petit, Berthold Technologies GmbH & Co KG

The combination of Open Architecture UPLC® with online radioactivity detection equipped with newly-designed admix or solid cells can significantly improve the separation and data quality for the identification of radio labelled metabolites.
Food Safety Analysis: LC/MS/MS Applications using New Kinetex® Core-Shell Technology HPLC/UHPLC Columns
Philip J. Koerner, Terrell Mathews, and Jeff Layne, Phenomenex

The availability of several bonded phases chemistries (PFP, HILIC, C18) on the ultra-high efficiency Kinetex core-shell technology provides orthogonal selectivity that is shown to be useful for the separation challenges presented in analyzing potential contaminants in food safety analysis.
Pneumovax 23 characterization with SEC-MALS
John MacNair, T. Desai, J. Teyral, C. Abeygunawardana, and J. Hennessey, Jr., Wyatt Technology Corporation

Size-reduced polysaccharides were analyzed as monovalent solutions by high-performance size exclusion chromatography (HPSEC) with multiangle light scattering (MALS) and refractive index (RI) detection to measure their absolute molecular weight.
New UHPLC Column Options offer Selectivity Refinement
Anne Mack, Agilent Technologies

Agilent Rapid Resolution High Definition (RRHD) Columns are now available in 8 phases, including four C18 phases. Stable to 1200 bar, these columns provide new opportunity to refine your analysis and get more from your UHPLC investment.
LC/HPLC

Determination of Ethylene Glycol and Diethylene Glycol
Terri Christison, Dionex Corporation

This note describes the use of two amperometric methods to quantify ethylene glycol and diethylene glycol in a sorbitol solution as per the new USP recommendations. Sorbitol is a common food additive.

Determination of Methacholine Chloride and Potential Impurities
Richard Kornfeld, Dionex Corporation

This note demonstrates an Reagent-Free Ion Chromatography system can determine methacholine, acetylcholine, and ß-methylcholine with good precision and accuracy.
To advertise or have an application note inserted, contact:

Lee Noyes
+44 1244 629315 | Email

Lindsay Jones
+44 1244 629316 | Email



You are subscribed to %%list.name%% as %%emailaddr%%. Click here to unsubscribe or edit your member profile.

To ensure delivery to your Inbox, please add %%email.list%% to your address book. If you need help doing this, click here.

Advanstar Communications provides certain customer contact data (such as customers' names, addresses, phone numbers and e-mail addresses) to third parties who wish to promote relevant products, services and other opportunities which may be of interest to you. If you do not want Advanstar Communications to make your contact information available to third parties for marketing purposes, simply call (toll free) 1-866-529-2922 at any time, or fax us at 1-218-740-6417. Outside the U.S., please phone 1-218-740-6395. Contact us by mail at Advanstar Communications Inc., Bridgegate Pavilion, 4A Chester Business Park, Wrexham Road, Chester, CH4 9QH, UK.