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Featured Application Note:
GC-MS/MS Analysis of OCPs, PAHs, and PCBs in Environmental Samples
Inge de Dobbeleer, Joachim Gummersbach, Hans-Joachim Huebschmann, Anton Mayer, Paul Silcock, Thermo Fisher Scientific
A high performance, highly productive analysis of OCPs, PAHs, and PCBs in environmental samples is conducted through a consolidated GC-MS/MS method. Smart software tools are integrated into the method development and analysis workflow to minimize the time needed to implement and maintain the methodology in routine. Read More |
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Seamless Instrument-to-Instrument Method Transfer of the EPA Method 8330A/B for Nitroaromatics From an Agilent 1200 Series LC to the Agilent 1290 Infinity Binary LC Using ISET
Angelika Gratzfeld-Huesgen, Agilent Technologies
This application note presents an application solution for the analysis of nitroaromatic compounds. The seamless transfer of the EPA method (8330A/B) from the Agilent 1200 Series Rapid Resolution LC (RRLC) to the Agilent 1290 Infinity Binary LC using Intelligent System Emulation Technology (ISET) is shown. Read More |
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Fast Separation of Pharmaceutical Anions and Cations
Terri Christison, John E. Madden, Fei Pang, and Khalil Divan
This application note demonstrates the advantages of using walk-up capillary ion chromatography for ultrafast separations of pharmaceutical relevant anions and cations. Identify and quantify inorganic impurities essential in drug development while using the benefits of an Always On, Always Ready IC system. Read More |
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Fast Analysis of Fruit Juice Acids with Poroshell 120 SB-Aq
William Long, Agilent Technologies, Inc.
The acid profile can be used to identify a juice or verify its purity. A reversed-phase HPLC method for separation of organic acids (tartaric, quinic, malic, citric, and fumaric acids) in fruit juices is demonstrated using an Agilent Poroshell 120 SB-Aq column. The chromatographic separation was performed using potassium dihydrogen orthophosphate buffer (pH 2.5) as mobile phase and diode array detection. Read More |
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SEC-MALS Characterization of Unfractionated Heparin
Lin Rao and John Beirne
Heparin has been used as an anticoagulant for over sixty years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution. The molecular weight of heparin ranges from 3 to 50 kDa, but, typically falls within the 10 to 20 kDa range for unfractionated heparins used in medical applications. In light of heparin contamination issues in 2008, USP has proposed to include heparin molecular weight determination for the stage 3 heparin monograph revisions. Read More |
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Metabolic Profiling of Yeast Sterols Using the Agilent 7200 Series GC/Q-TOF System
Manhong Wu, Robert St. Onge, Sundari Suresh, Ronal Davis, and Gary Peltz, School of Medicine and Biochemistry, Genome Center, Stanford University; and Sofia Aronova and Stephan Baumann, Agilent Technologies, Inc.
The 7200 GC/QTOF and Mass Profiler Professional (MPP) were used to determine the enzymatic targets of putative antifungal drugs. This was done by using high resolution and accurate mass MS and MS-MS data to determine the relative levels of ergosterol biosynthesis intermediates. Read More |
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Analysis of PNA in Jet Fuel by Flow Modulated GCxGC
Rob de Jong, PAC
AC Analytical Controls developed a robust solution that provides quantitative insight into the group type composition of jet fuels. The solution, based on flow modulated GCxGC uses advanced AC Flow modulation, simplifying hardware and avoiding the need for large volumes of liquid coolants normally required for cryogenic modulation. AC Flow Modulation yields better peak resolution and requires less operator intervention, making it suitable for routine lab operation. This application note discusses this new technique, which determines total paraffins, total naphtenes, and total aromatics (PNA) for jet fuel. Read More |
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GC-MS/MS Analysis of OCPs, PAHs, and PCBs in Environmental Samples
Inge de Dobbeleer, Joachim Gummersbach, Hans-Joachim Huebschmann, Anton Mayer, Paul Silcock, Thermo Fisher Scientific
A high performance, highly productive analysis of OCPs, PAHs, and PCBs in environmental samples is conducted through a consolidated GC-MS/MS method. Smart software tools are integrated into the method development and analysis workflow to minimize the time needed to implement and maintain the methodology in routine. Read More
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