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Screening and Identification with High Confidence based on High Resolution and Accurate Mass LC-MS/MS
Andre Schreiber, David Cox, AB SCIEX
This note describes a workflow and tools to identify targeted and non-targeted pesticides in fruits and vegetables. High resolution, accurate mass LC/MS/MS data is mined using advanced software tools to identify components based on retention times, accurate mass, isotopic pattern, and MS/MS library searching. |
Highly Sensitive UV Analysis with the Agilent 1290 Infinity LC System for Fast and Reliable Cleaning Validation – Part 2
Edgar Naegele, Katja Kornetzky, Agilent Technologies
This Application Note demonstrates the use of the Agilent 1290 Infinity LC in cleaning validation studies for high sensitivity monitoring of active pharmaceutical product residues in cleaning solutions. It shows that fast analysis is highly useful for cleaning validation, providing fast results and lower production equipment downtime. |
Rapid Tea Analysis on Poroshell 120 demonstrates similar selectivity to ZORBAX
Anne Mack, Agilent Technologies
An analysis of ten compounds (9 catechins + caffeine) commonly found in green tea demonstrates similar selectivity on Agilent ZORBAX SB-C18 and Agilent Poroshell 120 SB-C18. The 1.4 min gradient analysis on Poroshell 120 generates linear calibration curves for all ten compounds through LC/MS. Several bottled and brewed tea samples are quantified and compared. An unfiltered, undiluted brewed green tea sample demonstrates a lifetime of more than 1500 injections on the Poroshell 120 column with a dirty sample at high pressure. |
Enrichment and Identification of Chicken Ovalbumin Phosphopeptides
Pranathi Perati, Dionex Corporation
This note describes the enrichment and identification of chicken ovalbumin phosphopeptides by immobilized metal affinity and reversed-phase chromatographies. |
Faster Real-time Response to Bacterial Infection of Bioethanol Fermentation using a Short, Ion Exclusion Rezex™ ROA Column
Ngoc Nguyen, Michael McGinley, & Jim Mott, Phenomenex
Ethanol producers can easily reduce costs and improve operational efficiency by using the shorter Rezex ROA 150 x 7.8 mm column as an alternative to a longer 300 x 7.8 mm column. The shorter column will not only increase throughput by 50 %, but also reduce cost by utilizing less solvent for each HPLC run. |
Impurity Profiling of Carbamazepine by HPLC/UV
Terry Zhang, Guifeng Jiang, Thermo Fisher Scientific
This application note describes an accurate and robust HPLC/UV method for quantitative impurity analysis of carbamazepine which meets USP requirements and ICH guidelines. This simple HPLC/UV assay was developed using the Thermo Scientific Accela 1250 UHPLC system, a Hypersil GOLD CN column and a simple water/acetonitrile gradient. |
Pneumovax 23 characterization with SEC-MALS
John MacNair, T. Desai, J. Teyral, C. Abeygunawardana, and J. Hennessey, Jr., Wyatt Technology
Size-reduced polysaccharides were analyzed as monovalent solutions by high-performance size exclusion chromatography (HPSEC) with multiangle light scattering (MALS) and refractive index (RI) detection to measure their absolute molecular weight. |
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Totally Automated Sample Extraction, Cleanup and Direct to Vial Concentration of PBDEs in Soil
Phil Bassignani, FMS, Inc.
PBDEs have been used in a wide array of products, including building materials, electronics, furnishings, motor vehicles, airplanes, plastics, polyurethane foams, and textiles. The health hazards of these chemicals have attracted increasing scrutiny, and they have been shown to reduce fertility and linked to other toxicities in humans. The Sample Prep process for PBDEs has been shown to be particularly difficult when done manually due to outside contamination. This note shows how a totally automated closed system for Sample Extraction, Cleanup and Concentration lower the possibilities of sample contamination. |
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Ultra-Fast Analytical Method for the Sample Cleanup & LC/MS/MS Analysis of Chloramphenicol in Shrimp and Other Marine Food Products
Philip J. Koerner, Matthew Trass, Liming Peng and Jeff Layne, Phenomenex
A method for the analysis of Chloramphenicol in shrimp has been developed with a limit of quantitation (LOQ) of 0.001 ng/g in shrimp (0.001 ppb) based on the calibration standards. This is three hundred times lower than the current United States Food and Drug Administration (USFDA) method. The method described uses Strata-X solid phase extraction (SPE) cartridges for sample cleanup and concentration, followed by ultra-fast LC/MS/MS analysis (<5 minutes) using a Kinetex core-shell column. |
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Trace Nickel and Zinc in Power Plant Waters
Brian De Borba, Dionex Corporation
This note describes the determination of corrosive trace nickel and zinc in borated power plant waters containing lithium hydroxide using nonsuppressed conductivity detection. This method meets the monitoring requirements of many power plant companies using pressurized water reactors and is easy to setup. |
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To advertise or have an application note inserted, contact:
Lee Noyes
+44 1244 629315 | Email
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+44 1244 629316 | Email
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