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An Accurate and Robust LC–MS Method for the Identification of Illicit Drug Salt Forms
Guifeng Jiang, Terry Zhang, and Kathryn Preston, Thermo Fisher Scientific
Illicit cocaine, amphetamine, methamphetamine, and MDMA are often encountered in the form of salts, and identification of the specific counterion present may provide valuable information about the source of production and the manufacturing pathway. This application note describes a robust LC–MS method capable of detecting illicit drug salt forms for screening and identifying these stimulants in seized evidence. |
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Identification of Lysergic Acid Diethylamide (LSD) in Candy by UHPLC–MS
Jason R. Stenzel, Washington State Patrol – Crime Laboratory Division and Guifeng Jiang, Thermo Fisher Scientific
Lysergic acid diethylamide (LSD) is a controlled substance in forensic chemistry that is notoriously difficult to identify. This application note describes a method to quickly and positively identify trace amounts of LSD in sugar candy with minimal sample preparation and no chemical derivatization. |
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Identification of Cannabinoids in Baked Goods by UHPLC–MS
Jason R. Stenzel, Washington State Patrol – Crime Laboratory Division and Guifeng Jiang, Thermo Fisher Scientific
Cannabinoids in baked goods can be identified using UHPLC–MS with minimal sample preparation. This application note describes how a working forensic laboratory uses UHPLC–MS to analyze complex food matrices such as baked goods for three cannabinoids of forensic importance. |
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UHPLC–MS: An Efficient Tool for Determination of Illicit Drugs
Guifeng Jiang, Thermo Fisher Scientific
This application note presents an optimized UHPLC–MS method with respect to stationary phase, mobile phase, and detector settings to achieve picogram level quantitation of 14 drugs and metabolites employing a 12 min separation. |
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Confirmation and Quantitation of Expanded Panel of Sympathomimetic Amines in Urine
Mathew Lambing and Jason Cole, Thermo Fisher Scientific
A method for the confirmation and quantification of these sympathomimetic amines in human urine was developed which adheres to guidelines published by SAMHSA, the College of American Pathologists (CAP), the Society of Forensic Toxicologists (SOFT), and the European Workplace Drug Testing Society (EWDTS). The method was developed to demonstrate the performance of the ISQ GC–MS system for the analysis of five amphetamine-class compounds in a urine matrix. |
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Confirmation and Quantification of Phencyclidine in Urine Using the ISQ Single Quadrupole GC–MS
Matthew Lambing, Eric Phillips, and Trisa Robarge, Thermo Fisher Scientific
A forensic toxicology method for the confirmation and quantification of phencyclidine in human urine was developed using the Thermo Scientific ISQ Single Quadrupole GC–MS system. This method adheres to guidelines published by the United States Substance Abuse and Mental Health Services Administration (SAMHSA), the College of American Pathologists (CAP), the Society of Forensic Toxicologists (SOFT), and the European Workplace Drug Testing Society (EWDTS). |
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Confirmation and Quantification of Benzoylecgonine in Urine Using the ISQ Single Quadrupole GC–MS
Matthew Lambing, Eric Phillips, and Trisa Robarge, Thermo Fisher Scientific
As part of the new Mandatory Guidelines for Federal Workplace Drug Testing Programs, changes have been made for the confirmation of the cocaine metabolite, benzoylecgonine (BE) in urine. This forensic toxicology method for the confirmation and quantitation of benzoylecgonine in human urine was developed using the Thermo Scientific ISQ single quadrupole GC–MS system. |
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Confirmation and Quantitation of Cocaine and Major Metabolites in Urine Using the ISQ Single Quadrupole GC–MS
Matthew Lambing, Eric Phillips, Trisa Robarge, Thermo Fisher Scientific
Cocaine is metabolized in vivo resulting in the formation of ecgonine methyl ester (EME), norcocaine, and benzoylecgonine (BE). Cocaethylene (CE) is a substance formed when cocaine (COC) and ethanol are coadministered. A forensic toxicology method for the confirmation and quantitation of ecgonine methyl ester benzoylecgonine, cocaine, and cocaethylene in human urine was developed using the Thermo Scientific ISQ single quadrupole GC–MS system. |
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Confirmation/Quantitation THC Oral Fluid with MRM Method GC-Triple Quadrupole MS
Eric Chi and Jason Cole, Thermo Fisher Scientific
Analysis of oral fluids is becoming an increasingly popular biological fluid as an alternative to blood and urine to analyze for drugs of abuse. The methodology presented in this note focuses on the use of the Thermo Scientific TSQ Quantum XLS GC–MS-MS for the confirmation and quantitation of THC in an oral fluid matrix. |
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