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Featured Application Note:
Screening of 20 Benzodiazepines and Four Metabolites in Whole Blood using UHPLC-MS/MS
By Carine Roussel, Marie Spiandore, Marianne Lacmari, Benedicte Duretz
Read about a rapid method for quantifying benzodiazepines. A timed selected reaction monitoring (T-SRM) method was used to increase the acquisition time per compound and achieve better signal-to-noise ratios for the analytes. The precision of the analysis meets current consensus guidelines. |
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Differentiating Cosmetic Products by Py-GCxGC-TOFMS
LECO
Increasing complexity of cosmetics makes it hard to differentiate for competitor awareness & deformulating applications. Minimal sample prep and more than five times as many peaks were found in each cosmetic brand when the LECO Pegasus 4D Py-GCxGC-TOFMS was used for the analysis. For fast, automated comparison of samples the LECO ChromaTOF Compare feature was used. |
Analysis of a betel-nut foodstuff by direct thermal desorption
Gareth Roberts, Daniel Cooper, Markes International Ltd
This Application Note describes the determination of the complex VOC profile of an Indian betel-nut foodstuff by thermal desorption-GC/MS, and the rapid identification of the constituent compounds, even at low-concentration, by comparison against a library of flavor/fragrance compounds using TargetView™ software. This is an important application because of the widespread use of foodstuffs, such as this, for chewing, some of which contain components known to be the cause of oral cancer. |
Lower Detection Limits of Volatile Nitrosamines in Tobacco by GC-MS/MS
Mary Dennis, Charles Lyle, Eric Phillips, Thermo Fisher Scientific
Volatile nitrosamines (VNA) are a class of compounds that are known to pose significant health risks in tobacco. This application note describes a method demonstrating the use of the Thermo Scientific TSQ Quantum XLS triple quadrupole GC-MS/MS system and the use of timed selected reaction monitoring (t-SRM) for the analysis of smokeless tobacco for VNA. |
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A New Solution to Selectivity Challenges
Yves Leblanc, Doina Caraiman, Mauro Aiello and Hesham Ghobarah, AB SCIEX
High selectivity is a key component of successful quantitative bioanalysis. Differential ion mobility spectrometry presents an attractive option to increase selectivity by introducing an additional dimension of separation during the sample introduction, following atmospheric pressure ionization. The AB SCIEX SelexION™ Technology with the QTRAP®5500 system brings the power of differential ion mobility separation to complex bioanalytical assays. |
An Improved HPLC Method for the Determination of Ranitidine Suitable for All Dosage Forms using Kinetex® Core-Shell Technology HPLC/UHPLC Columns
Philip J. Koerner, Sky Countryman, Deborah Jarrett, and Jeff Layne, Phenomenex
A new and improved HPLC method based on core-shell technology has been developed to replace the various testing protocols in the existing Ranitidine HCl monographs for various dosage forms. |
Minimizing Matrix Interferences in Bioanalysis with the ACQUITY UPLC I-Class coupled to Tandem Quadrupole MS/MS
Joanne Mather and Robert S. Plumb, Waters Corporation
Using the high-resolution Waters ACQUITY UPLC I-Class System for bioanalysis, fluticasone propionate and salmeterol xinafoate are successfully resolved from matrix interferences in a dried blood spot card, and from endogenous material in rat plasma samples. |
Hydroxyethyl Starch Characterization by Light Scattering
Wyatt Technology
Hydroxyethylstarches (HES) are used increasingly as plasma expanders in medical applications. By coupling FFF technology to a multi angle light scattering (MALS) detector, absolute values can be determined without making any assumptions. |
Analysis of Water-Soluble Vitamins from Multivitamin Tablets for Nutrition Labeling
Siji Joseph, Agilent Technologies
Separation and quantification of water soluble vitamins was done on an Agilent 1260 Infinity LC system using a Poroshell EC-C18 Column and UV detection. Finally, this method was effectively transferred to a fast UHPLC method using an Agilent 1290 Infinity LC system. |
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Automated One Step SPE and Concentration of Nitrogen and Phosphorus Containing Pesticides in Water
Phillip Bassignani, FMS,Inc.
Replacing organochlorine pesticides, nitrogen and phosphorus containing pesticides are widely used both domestically and globally. Initially considered more desirable than organochlorine pesticides because of their rapid breakdown in the environment, they operate by inhibiting the enzyme acetylcholinesterase disrupting nerve function. They have been shown, particularly organophosphates, to
be extremely toxic to vertebrates. |
Improved Extraction and LC/MS/MS Analysis of Barbiturates from Urine Samples using Strata™-X-Drug N SPE and Kinetex® Core-Shell HPLC/UHPLC Columns
Matthew Trass, Michael Rummel, Seyed Sadjadi, Jeff Layne, Sky Countryman, Erica Pike, Phenomenex
Utilizing a fast and simplified Solid Phase Extraction (SPE) procedure with Strata-X-Drug N, barbiturates from urine samples were concentrated and cleaned prior to LC/MS/MS analysis. This SPE sorbent was specifically designed and QC’d for neutral drugs of abuse analysis and does not require conditioning or equilibrating steps, saving both time and solvent while providing high recoveries at the 300 ng/ mL cutoff level. |
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Determination of Total Phosphorous in Wastewater
Thunyarat Phesatcha, Suparerk Tukkeeree, and Jeff Rohrer, Dionex, part of Thermo Fisher Scientific
This note describes a proposed ASTM method using ion chromatography using carbonate eluents and a second method that uses hydroxide eluents with an eluent generator for the successful analysis of phosphorous in wastewater. |
Glycerol in Biodiesel
Terri Christison, Dionex, part of Thermo Fisher Scientific
This note describes an HPAE-PAD method to accurately and selectively determine free and total glycerol from aqueous extractions of biodiesel samples and base-hydrolyzed biodiesel samples, respectively. HPAE-PAD is a sensitive and selective method that does not require sample derivatization, and therefore is the method of choice when determining µg/kg to mg/kg concentrations of carbohydrates. |
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To advertise or have an application note inserted, contact:
Lee Noyes
+44 1244 629315 | Email
Lindsay Jones
+44 1244 629316 | Email
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