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PharmTech
November 2018
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In This Issue

Build your pharma development and manufacturing knowledge base with the latest whitepapers, application notes, posters, and other educational resources from bio/pharma industry suppliers.

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FEATURED WHITEPAPER

Solid Lipid NanoParticles

Lubrizol LifeSciences

Solid Lipid Nanoparticles (SLNs) provide an effective tool for encapsulating and delivering both small-molecule hydrophobic and large hydrophilic APIs. SLNs are low cost, easy to manufacture, and versatile.

Formulation

Considerations for Development of Lyophilized Biosimilar

Lindsay Weigel, PhD and Gregory Sacha, PhD; Baxter BioPharma Solutions

The patents for a number of parenteral biologic formulations are destined to expire in the United States between 2016 and 2027. This provides development opportunities for many companies, but also provides significant challenges.

Manufacturing

Analysis Using Counter-Rotating Twin Screw Extruder

Brian Machado, Abbe Haser, Feng Haight, Charlie Martin, and Augie Zhang; Leistritz Extrusion

Various extrusion operating conditions and formulations were used to enhance the solubility and recovery of Meloxicam (MLX) in copovidone to near 100% on a counter-rotating twin screw extruder (TSE).

Packaging

Sanofi Pasteur Case Study–Top Load Cartoning in Combination with Monomaterial Packaging

Peter Grassl; Dividella AG

Find out how Sanofi Pasteur achieved sensational results by using topload cartoning in combination with monomaterial packaging, resulting in 50% lower packaging volume thus 50% reduction in the cold-chain, distribution, and storage costs.

Quality

Top 3 Processes to Automate to Improve Quality Management

ETQ

Quality professionals recognize that streamlining processes can deliver significant returns, but many are unsure where or how to start. With dozens or even hundreds of processes, automating them all can seem overwhelming.
In fact, research shows that while a majority of companies want to automate critical quality processes, less than half of them have actually made the leap.

Applications in Pharmaceutical Manufacturing

Alconox, Inc.

The use of aqueous cleaning in pharmaceutical manufacturing can provide numerous benefits in terms of effectiveness, minimal surface residue, and easier cleaning validation.

Supply Chain

The Benefits of On-Dose Product Identification

Barry McDonogh, senior vice-president, Business Development; TruTag Technologies, Inc.

The introduction of on-dose product identification technologies provides the pharmaceutical industry with a powerful new tool to manage supply-chain risk.

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