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Pharmaceutical Technology/BioPharm Marketplace eNewsletter

Pharmaceutical Sciences, Manufacturing & Marketplace Report August 28, 2013
  From Cynthia Challener, PhD, Editor, Pharmaceutical Sciences, Manufacturing & Marketplace Report
In this issue, researchers from Millennium: The Takeda Oncology Company employ memory of chirality to install a chiral quarternary carbon center in the large-scale preparation of a new TORC1/2 inhibitor. Also, UCLA researchers develop nanoencapuslation technology that may emable targeted delivery of injectable biopharmaceutical therapies. Plus reports on an accessible cell-imaging system that provides rich cellular visualization analysis, porous silica gel glidants for direct tablet compression of moisture-sensitive APIs, and single-use systems at Catalent Pharma Solutions' new biomanufacturing facility.		  
 

   
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Chemical API Manufacturing
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Alfred Pasieka/Getty Images

Takeda Researchers Achieve Kilogram-scale GMP Production of a TORC1/2 Inhibitor

Installation of a quaternary chiral center with high enantioselectivity using memory of chirality enabled the six-step synthesis of the desired active compound. Click Here to Read More

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Parenterals
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Maria Toutoudaki/Getty Images
UCLA Researchers Develop Nanocapsule for Targeted Delivery of Large-Molecule APIs

Reversible nanoencapsulation technology may make it possible to deliver high molecular weight drugs directly to target cancer cells, increasing efficacy and reducing side effects. Click Here to Read More
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Pharmaceutical Analysis
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Making Cell Imaging Systems More Accessible

Conventional cell imaging systems that provide high quality data can be very expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues. Click Here to Read More
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Solid, Semisolid, and Specialty Dosage Forms
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Porous Silica Gel Glidants Aid Direct Tablet Compression

Direct tablet compression is simpler than wet or dry granulation, but obtaining the right flow properties to ensure good compaction and uniform drug distribution can be a challenge. Porous silica gel, when used as a glidant, can address these critical issues.Click Here to Read More

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Biological API Manufacturing
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Catalent Moves Forward with New Single-Use Biopharmaceutical Manufacturing Facility

Extensive adoption of single-use technologies and unidirectional flow reduces cross-contamination risk in the company’s new biomanufacturing facility. Click Here to Read More

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Other Recent Developments

Merck–PITT Collaboration Demonstrates Rapid Method for Evaluation of Residual Palladium
A simple, rapid analytical method for the determination of palladium in pharmaceutical production samples will speed up development and optimization of reactions involving palladium catalysts.

Collaboration Formed to Develop Large-Scale Bioreactor Production of Stem Cells
EMD Millipore and PharmaCell have entered into a collaboration to develop optimized large-scale expansion and harvest of HepaRG cells using bioreactor technology.

Tetraphase Pharmaceuticals Achieves Process-Scale Synthesis of New Tetracycline Derivative
Synthesis of tetracycline derivatives with novel substituents has been challenging. Using an approach based on a Michael−Dieckmann reaction, new compounds with enhanced antibiotic properties are now being prepared on a large scale.

Parallel Screening of Solid-State Characteristics Aids Formulation of Poorly Soluble Drugs
Rapid screening of critical API properties can quickly identify the best approach for increasing bioavailability.

Experts from Novo Nordisk, Baxter Discuss Technological Advances in Addressing the Challenge of Extractables and Leachables
Understanding the supply-chain challenge and coupling high-efficiency chromatographic techniques with information-rich detectors are leading to improvements in the management of extractables and leachables in parenteral drugs.

 
The Pharmaceutical Sciences, Manufacturing & Marketplace Report is a biweekly newsletter of Pharmaceutical Technology and BioPharm International, and an exclusive feature of the new Pharmaceutical Technology/BioPharm International Marketplace, an online community focused on products and services for drug development and manufacturing. The Pharmaceutical Sciences, Manufacturing & Marketplace Report provides insight in five main communities: solid, semisolid, and specialty dosage forms; parenterals; chemical API manufacturing; biological API manufacturing; and pharmaceutical analysis.  
 
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Perspectives from Cynthia Challener, PhD, editor of the Pharmaceutical Sciences, Manufacturing & Marketplace Report and industry members
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