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Pharmaceutical Sciences, Manufacturing & Marketplace Report October 9, 2013
  From Cynthia Challener, PhD, Editor, Pharmaceutical Sciences, Manufacturing & Marketplace Report
In this issue, GlaxoSmithKline, Novartis, and AstraZeneca fund a research center focused on advancing commercial-scale continuous crystallization. Pfizer, Eli Lilly, and several other pharmaceutical companies participate in the development of a modular sterile sampling system that integrates on-line and off-line cell analysis results for improved PAT in biopharm manufacturing. Plus, analysis of temperature-responsive polymers for on-demand drug release, a new plasmon resonance microscopy method that enables the analysis of living cells, and a single-use sterile fill-finish facility.		  
 

   
Stay current in the fast-paced world of biopharmaceutical and pharmaceutical development and manufacturing with a free subscription to the Pharmaceutical Sciences, Manufacturing & Marketplace Report.
 
Chemical API Manufacturing
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GlaxoSmithKline, Novartis, and AstraZeneca Fund Center Focused on Advancing Commercial-Scale Continuous Crystallization

Through partnerships and collaborations between academia, industry, and the public sector, the Center for Continuous Manufacturing and Crystallization is advancing continuous crystallization technologies. Click Here to Read More

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Biological API Manufacturing
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Sterile, Automated Sampling Enabling PAT for Biopharmaceutical Manufacturing

Pfizer, Eli Lilly, and several other pharmaceutical companies are participating in the development of automated sampling technology and associated software that improve process control and reduce development times in biopharmaceutical manufacturing. Click Here to Read More
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Solid, Semisolid, and Specialty Dosage Forms
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On-Demand Drug Release Possible with Thermo-Responsive Polymers

On-demand drug release has the potential to reduce the side effects associated with the over-dosage of drugs, particularly for highly potent anti-cancer therapies. Click Here to Read More
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Pharmaceutical Analysis
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Plasmon Resonance Microscopy Enables Analysis of Molecular-Scale Phenomena in Living Systems

Plasmonic imaging overcomes the limitations of traditional microscopy and can be used for the analysis of single cells, cell organelles, viruses, and even single protein-protein interactions.Click Here to Read More

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Parenterals
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Leveraging Singe-Use Learnings in Fill–Finish Operations

After realizing benefits from the adoption of a single-use filling line for one specific product, Patheon took the leap and installed a single-use filling line in a new facility. Click Here to Read More

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Other Recent Developments

Pfizer Applies Integrated Technology for Cell-Line Development of Proprietary Antibodies
Pfizer advances its pipeline of antibody-based therapies using a host cell line that combines engineered glycosylation technology and enhanced gene expression.

Exploring Single-Use Systems for Fill–Finish Operations
The need to develop a final formulation process for a parenteral product sensitive to stainless-steel gave Patheon the opportunity to evaluate the potential of single-use technology in fill–finish operations.

GlaxoSmithKline Adopts Continuous Manufacturing for Preparation of Key Intermediate
Use of a continuous-flow reaction made it possible to scale up a highly exothermic reaction for the production of a key Suzuki–Miyaura coupling reagent.

Laser Headspace Analysis Advantageous for Monitoring Sterile Fill–Finish Operations
Measuring headspace gas composition and pressure allows sterile product manufacturers to simultaneously monitor important quality parameters rapidly and nondestructively.

Granulation Method and Process Monitoring Matter
The characteristics of tableted solid dosage drugs often depend on the granulation process, so selecting the most appropriate granulation technique and monitoring the process are crucial.

 
The Pharmaceutical Sciences, Manufacturing & Marketplace Report is a biweekly newsletter of Pharmaceutical Technology and BioPharm International, and an exclusive feature of the new Pharmaceutical Technology/BioPharm International Marketplace, an online community focused on products and services for drug development and manufacturing. The Pharmaceutical Sciences, Manufacturing & Marketplace Report provides insight in five main communities: solid, semisolid, and specialty dosage forms; parenterals; chemical API manufacturing; biological API manufacturing; and pharmaceutical analysis.  
 
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Perspectives from Cynthia Challener, PhD, editor of the Pharmaceutical Sciences, Manufacturing & Marketplace Report and industry members
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