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Pharmaceutical Sciences, Manufacturing & Marketplace Report November 13, 2013
  From Cynthia Challener, PhD, Editor, Pharmaceutical Sciences, Manufacturing & Marketplace Report
In this issue, examining advances in site-specification conjugation for antibody drug conjugates and improved processing mapping in fill-finish operations. Plus, advances in fluorination chemistry in pharmaceutical syntheses, and FDA's emphasis on quality metrics.		  
 

   
Stay current in the fast-paced world of biopharmaceutical and pharmaceutical development and manufacturing with a free subscription to the Pharmaceutical Sciences, Manufacturing & Marketplace Report.
 
Biological API Manufacturing
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Maciej Frolow/Getty Images

Site-Specific Conjugation of Cytotoxic Cytolysins Could Lead to Highly Effective Antibody-Drug Conjugates

Recent collaboration offers more heterogeneous, stable antibody drug conjugates of synthetic tubulin-binding agents shown to rapidly trigger cancer cell death. Click Here to Read More

Join our Biological API Manufacturing Linked-In Community
Parenterals
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Maria Toutoudaki/Getty Images
Careful Process Mapping Can Significantly Reduce Product Losses in Fill-Finish Operations

Changes in the working procedures and disposable fluid flow paths resulted in a measurable decrease in product waste in a low-volume, high-value fill-finish line. Click Here to Read More
Join our Parenterals Linked-In Community
 
Chemical API Manufacturing
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Alfred Pasieka/Getty Images
Overcoming Challenges in Fluorine-Based Chemistry

Fluorinated molecules are important as pharmaceutical compounds. Recent advances involve selective and late-stage insertion of fluorine into small molecules. Click Here to Read More
Join our Chemical API Manufacturing Linked-In Community
 
Pharmaceutical Analysis
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Adam Gault/Getty Images

FDA Seeks Metrics to Define Drug Quality

Manufacturing standards are considered key to preventing drug recalls and shortages. Click Here to Read More

Join our Pharmaceutical Analysis Linked-In Community
 
Solid, Semisolid, and Specialty Dosage Forms
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Ion-Bogdan Dumitrescu/Getty Images

Tablet-Sticking Solutions

Screening methods and predictive models address tenacious tablet-sticking problems. Click Here to Read More

Join our Solid, Semisolid, and Specialty Dosage Forms Linked-In Community
 
Other Recent Developments

Science-Based Technical Report Being Developed to Ensure Effective Use of Blow-Fill-Seal Technology
The Parenteral Drug Association has established a task force to develop a peer- and regulatory agency-reviewed Technical Report that will serve as a science-based industry reference document.

New Technology Enables Integrated Chromatographic Separation and Mass Detection
Mass detection at the push of a button could change the way many laboratories carry out their chromatographic analysis.

New Single-Use Bioreactor Technology Emphasizes Ease-of-Use and Intelligent Process Control
An updated bioreactor based on rocking technology has more advanced controls but is easier for biopharmaceutical manufacturers to use.

Quality by Design in APIs
The adoption of quality by design in small-molecule drug development and manufacturing continues to evolve as the industry seeks ways to augment process understanding for APIs.

Evaluating Strategies for Oral Absorption Enhancement
Formulation scientists tackle the challenges of improving drug absorption across the gastrointestinal membrane.

 
The Pharmaceutical Sciences, Manufacturing & Marketplace Report is a biweekly newsletter of Pharmaceutical Technology and BioPharm International, and an exclusive feature of the new Pharmaceutical Technology/BioPharm International Marketplace, an online community focused on products and services for drug development and manufacturing. The Pharmaceutical Sciences, Manufacturing & Marketplace Report provides insight in five main communities: solid, semisolid, and specialty dosage forms; parenterals; chemical API manufacturing; biological API manufacturing; and pharmaceutical analysis.  
 
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Perspectives from Cynthia Challener, PhD, editor of the Pharmaceutical Sciences, Manufacturing & Marketplace Report and industry members
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