Pharmaceutical Technology Whitepaper Alert:
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Pharmaceutical Technology Featured Whitepapers
June 2011

Featured Whitepaper: Surety LLC
Protect Your Scientific Intellectual Property for the Long Term
Can your electronic research IP records withstand a court challenge?
Sponsored By: Surety, LLC

As more pharmaceutical, bio-sciences and R&D-centric firms move to electronic lab environments, your digital scientific research, formulas and clinical findings are your scientific Intellectual Property. Protecting the integrity and legally defending the authenticity and ownership of such electronic data is critical to your organization’s long-term success. But if you are overlooking this protection in your lab management workflows, you risk losing patent ownership, revenue and consequently your business, if you can't prove authenticity and time of creation, hence your ownership, in a court of law.

This new whitepaper from IP Protection Leader, Surety, explores these concepts and requirements, and discusses how you can implement simple, cost-effective controls to achieve legally defensible scientific IP for the life of the research records.

 
 
Outsourcing
   
  Contract Services
   
 
Quantification of Elemental Extractables in Drug Container Closures
Author: Anthony Grilli
Sponsored By: SGS Life Science Services

This paper describes the impact of varying extraction and analytical techniques on metal contaminant quantification of drug container closures. This study focuses primarily on elemental extractables as defined by USP.
 
VC-funded Start-ups: How to Fast Track Product Development through Custom Chemistry Outsourcing Services
Authors: Christopher Kulp and Linda Tedeschi Miller
Sponsored By: Richman Chemical Inc.

In order for privately funded, emerging technology start-ups to succeed, novel technologies must be developed and advanced in an accelerated manner. Venture Capitalists can increase their ability to achieve a better and faster return on this type of investment when they recommend the services of Richman Chemical Inc.
 
Ingredients
   
  Cold Chain
   
 
Buyer's Guide to Cold Chain Shipping
Author: Eric Kinaitis
Sponsored By: FedEx Custom Critical

A concise how-to guide on how to evaluate transportation providers and their capabilities as they relate to temperature-controlled shipping.
 
manufacturing
   
  Manufacturing
   
 
AQUEOUS CRITICAL CLEANING: APPLICATIONS IN PHARMACEUTICAL MANUFACTURING
Authors: Malcolm McLaughlin, Theresa Dowds
Sponsored By: Alconox

This Guide to Critical Cleaning places a concise overview of our half-century of experience at your fingertips. From tablet presses to mixing tanks, Alconox detergents handle tough critical cleaning jobs—like removing insoluble coatings residues. The benefits of employing aqueous cleaning in pharmaceutical manufacturing are numerous.
 
Hot Melt Extrusion (HME) - nano-scale compounding developments
Author: Charlie Martin
Sponsored By: Leistritz

Hot melt extrusion is emerging as a preferred manufacturing methodology for dosage forms. The high cost and limited availability of raw materials during the development phase has resulted in the need to process small amounts of API’s/excipients via extrusion to determine process viability. Experimental data is presented on a new twin screw extrusion device that can process as little as 20 to 100 gram micro-batches, as well as a scale-up path.
 
Provide Precise, Seamless Liquid Filling
Author: Gregg E. Johnson
Sponsored By: Thermo Fisher Scientific, Fluid Handling, Barrington, IL, USA

Sterile liquid flow is paramount in pharmaceutical and bioprocessing applications, which is why Thermo Scientific Masterflex peristaltic pumps are highly-suited for these demanding processes.
 
 
Lab Equipment
   
  Lab Equipment
   
 
Quantitation of Nucleic Acid Using a Micro-volume Spectrophotometer
Sponsored By: Shimadzu
This application highlights measurement of dsDNA at various concentrations at each optical pathlength of a small-volume spectrophotometer, as well as carryover performance using a unique automatic wiping function.
 
Determination of Low Concentration Methanol in Alcohol by Affordable High Sensitivity Raman Instrument
Authors: Duyen Nguyen and Eric Wu
Sponsored By: Enwave Optronics

We present Raman spectroscopy as a quick and lower cost alternative to verifying the existence of low concentration methanol in alcohol.
 
Ingredients
   
  Ingredients
   
 
Cold Water Granulation Using Pregelatinized Starch
Authors: Susan Freers, Carrie Shipley
Sponsored By: Grain Processing Corporation

Quality granulations can be made using only cold water as the binding solution and fully pregelatinized corn starch as the binder. Using Spress® B825 Pregelatinized Corn Starch NF in the manner described eliminates solution preparation and simplifies the granulation process which accelerates production resulting in cost reduction.
 
Handheld Analyzers for the Screening of Pharmaceutical Counterfeits
Author: Julien Bradley
Sponsored By: Thermo Fisher Scientific

In an age where smartphones and computers are becoming both smaller and more powerful, it may come as no surprise that the same trend is starting to catch on with sophisticated instruments formerly relegated to analytical chemistry laboratories.
 
packaging
   
  Packaging
   
 
PTECH
Authors: Ryan Schuelke And Jeff Lagrange
Sponsored By: ENERCON INDUSTRIES

Step by step instructions for setting up an operating window for your induction cap sealer. Maximize your ability to Achieve a Perfect Seal by overcoming process & material variables.
 
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