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June 2011  
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Analyzing Aggregate-Detection Methods
Two popular methods for detecting protein aggregates are analytical ultracentrifugation and size-exclusion chromatography–multiangle light scattering. These techniques’ results correlate relatively well, but each one has its own strengths.

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In The Mixer

Basic Equipment-Design Concepts to Enable Cleaning in Place: Part I
The author describes the benefits and challenges inherent to cleaning in place (CIP). The article also describes the development and validation of a CIP cycle.

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>>Coming Soon: For an interview with Lawrence D. Sloan, president and CEO of the Society of Chemical Manufacturers and Affiliates, see the July issue of Pharmaceutical Technology Sourcing and Management.

 
Troubleshooting Editor's Picks

Dying Diaphragm Valves

Our company is getting low and unpredictable cycle life out of our diaphragm valves. This problem has caused us to implement standard operating procedures for frequent replacement of the diaphragms, which is costly and time consuming. What could be happening, and what are our options?


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Editor's Pick product

Editor's Pick product

Meissner’s inline UltraCap H.D. assembly is a ready-to-use, integrally sealed filter and housing system.
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Editor's Pick product

Telstar’s new automatic vial-loading and -unloading system operates under aseptic conditions and is compatible with conventional cleanroom and barrier technologies.
Read More at PharmTech.com
 
Showcase (Sponsored)
RoTab T R & D Tablet Press
The portable RoTab T offers precise scale-up to free up production machines from trials. The cGMP design enables easy validation for the production of small tablet batches and pre-clinical studies.
  • automatic tablet weight regulation via filling depth
  • seamless RPM adjustment for die table and Optifiller
  • servo-driven compression roll stations
  • optional servo-driven tablet hardness adjustment
  • automatic punch lubrication with adjustable intervals
http://www.fette-compacting.com/next
Editor's Pick product
 
Providing Consulting, Product Development, and Testing of Adhesives and Specialty Coatings for the Pharmaceutical Industry.
www.chemsultants.com/markets/medical-pharmaceutical.aspx
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The Palltronic® Flowstar IV filter integrity test instrument is fast, accurate and designed for use in laboratories or cleanrooms. Offering the latest networking and automation options, it is supported by extensive qualification documentation with worldwide technical and aftersales support.
For more information, please email flowstar@pall.com

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Product Announcements
  • The Firechek FC-4 Series valve from Assured Automation immediately vents the pneumatic actuator and closes the actuator air-supply line when it senses excessive heat from a nearby fire.
  • Banner Engineering’s line of VSM Series Micro Sensors is designed for optimal performance in applications subjected to heavy washdown and harsh chemicals.
  • FreightWatch International, a logistics security services provider, offers real-time temperature monitoring in conjunction with its suite of cargo-monitoring capabilities.
  • Hosokawa’s Powder Tester PT-X employs Carr indices to determine the flowability and floodability of dry powders.
  • The ACQUITY UPLC I-Class chromatography system from Waters is designed to provide low system dispersion and low carryover, thus facilitating difficult separations.


Calendar of Events
  • Jun. 29–30: Dry Powder Inhalers: The Next 25 Years (London). This conference will highlight new device technology and provide updates about formulations, biologics, generic drugs, and emerging markets.
  • Jul. 6–7: Social Media in the Pharmaceutical Industry (London). This event is focused on keeping attendees up-to-date with developments in the ever-changing social-media sphere.
  • Jul. 11–15: From Concept to CE Marking: The Medical Device Summer School (London). This conference is designed to map the processes from device concept to marketing and show how regulatory, quality, and clinical aspects of device development are joined into a continuous process.
  • Jul. 13–15: CPhI Japan (Osaka, Japan). An extensive program of conferences, seminars and exhibitor presentations will be presented alongside the events, providing the opportunity to learn about the latest innovations, technologies, and Japanese market trends.
  • Aug. 1–3: CoSMoS 2011 (Chapel Hill, NC). Each year, the topics at this conference reflect the issues facing practitioners with discussions developed and led by notable names in pharmaceutical practices.



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Editorial: email Erik Greb
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