The Continuous Quest for Process Improvement
Continuous manufacturing could bring the pharmaceutical industry advantages such as improved product quality, easy scale-up, flexibility, and short cycle times. But how can a company switch from batch to continuous manufacturing?
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Filling Now for the Future
Recent developments demonstrate the importance of biologicals, which usually are delivered through injections, for the drug industry’s future. To find out about the process of manufacturing prefilled syringes, and to learn about innovations in filling lines,Equipment and Processing Report talked to Thomas Otto, managing director of Vetter.
>>Coming Soon: For a snapshot of trends in innovation and spending on pharmaceutical manufacturing equipment, see the results of our annual survey in the April issue of Pharmaceutical Technology.
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Integrated Custom Air handlers (ICA) from Munters (Amesbury, MA) are designed to help integrate desiccant dehumidifiers into other air-conditioning components.
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The updated Mini and Micro series agitator bead mills from NETZSCH Fine Particle Technology (Exton, PA) have a smaller footprint than earlier versions of the machines. |
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Spirax Sarco, Inc.
The BT6-B Sanitary Thermostatic Steam Trap attains large CIP/SIP condensate discharge capacities with minimal back-up and sub-cooling. The trap opens approximately 3.6°F (2°C) below steam temperature at discharge pressures of
36 psig (2.5 barg) or less. Its ball-shaped valve and seat promote high-capacity flow and free drainage across the entire load range.
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New Filling System for Disposables
Optima Group pharma’s INOVA H10-16 is the latest in syringe-filling technology, producing 60,000 syringes per hour.
The benefits of disposable technology include reduction of qualification and validation costs, time consumption for
cleaning cycles are redundant, prevention of cross-contamination and highly flexible applications are just a few.
Drawing on decades of comprehensive experience with human vaccine filling machines, Optima Group pharma is
a solid one-stop supplier.
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Midwesco’s Pleat+Plus® filter
Midwesco’s Pleat+Plus® filter elements can increase the filtration surface area in your baghouse system by signi?cantly reducing the air-to-cloth ratios.
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Fluid-bed dryer bags
Kavon provides custom replacement fluid-bed dryer bags for US and European equipment models. The bags are appropriate for wet granulation, dry filtration, and wet and dry coating applications. The company offers flexible 1–4-bag systems in various fabrics choices and also repairs bags. Kavon Filter Products, Wall Township, NJ ¦ www.kavonfilter.com ¦ tel. 732.938.3135
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DJS Enterprise
Since 1991 specializing in high quality New and Used Equipment for the process and packaging Industries.
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FLUID BED DRYER FILTER BAGS
Shaffer Products is a premier manufacturer of fluid bed dryer bags with 60+ years of experience serving the pharmaceutical industry. Shaffer offers a wide range of static conductive fabrics in woven or screen cloths to choose from. Shaffer has recently introduced a range of innovative fabrics combining submicron level filtration with static conductivity and unmatched powder release. Shaffer Products, Union, NJ, www.shafferproducts.com; tel 800-992-5684
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HygroGen 2
Precision Humidity and Temperature Generator
Based on the AIRCHIP3000 DIGITAL TECHNOLOGY
Calibration of all your humidity and temperature measuring equipment is now a reality with the next generation HygroGen. The unit is a self-contained, transportable generator with unparalleled chamber uniformity and stability.
FEATURES:
Accurate, Fast Responding, Wide Ranging 5…95%RH and 0…60°C, Transportable, Touch-Screen Interface, USB connectivity, Automatic Profiling
APPLICATIONS:
Calibration and Metrology Laboratories, Pharmaceutical Instruments, BAS/HVAC transmitters, Data loggers and recorders, Industrial equipment
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- Vac-U-Max (Belleville, NJ) provides various vacuum receivers, including a straight-sided hopper for fast and efficient handling of dry materials in pneumatic conveyor systems.
- Millrock Technology (Kingston, NY) offers hydrogen-peroxide sterilization for freeze dryers. Hydrogen-peroxide sterilization is considered a safer, more efficient, and more environmentally friendly method of sterilization than steam sterilization.
- Eriez’s (Erie, PA) E-Z Tec DSP narrow-profile, liquid line metal detectors detect ferrous, nonferrous, and stainless metal contaminants in products such as liquids, slurries, syrups, pastes, and other pumped materials.
- Videojet Technologies offers the Wolke m600 advanced thermal inkjet printer, which enables high-speed, high-resolution coding of serialized data and barcodes, thus satisfying pharmaceutical and ePedigree coding requirements.
- Kaeser’s (Fredericksburg, VA) Com-paK Plus rotary lobe blower packages operate at ranges of 5–200 hp with flows of 60–2295 scfm.
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- March 24–26: Root Cause Analysis for CAPA (Dublin). This course is intended for all personnel concerned with quality and the analysis and correction of problems. The material presented will be of value to personnel of various levels of expertise and will emphasize the pragmatic. It will be particularly valuable to those new to this field and those who wish to refresh their knowledge of these technologies.
- April 13–14: Biopharmaceutical Change Control (San Diego, CA). In the life cycle of biopharmaceuticals, manufacturing change is unavoidable. Owing to the complex nature of the biopharmaceutical product, physicochemical and functional changes occur that can affect the product’s safety and efficacy. This three-track event looks at manufacturing change, its potential consequences, and industry experiences.
- April 20–22: INTERPHEX 2010 (New York). For more than 30 years, Interphex has been a large meeting place for professionals seeking leading-edge technology, education, products, services, capabilities, and networking. The show is geared toward scientific and process innovation in regulated drug manufacturing.
- April 26–28: Strategies against Counterfeit Medicines (Wurzburg, Germany). The aim of this conference is to present the regulatory authorities’ activities and the pharmaceutical industry’s initiatives to develop and establish appropriate counterfeit protection systems. The conference will focus on effective and affordable strategies, improve collaboration among regulators and the pharmaceutical industry, and discuss actions in the global fight against counterfeits.
- April 27–29: Technopharm 2010 (Nuremberg, Germany). The rapidly growing markets for cleanroom technology place exacting demands on apparatuses, plants, and processes. TechnoPharm is a high-tech exhibition that presents the range of products purely for this market segment. It is an established European exhibition forum for production, research, solid and liquid forms, validation, cleanroom technology, analysis, practice, and theory.
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Poll: |
>>Ingredient Suppliers
When sourcing raw materials and non-GMP intermediates or other chemicals, where are the majority of your suppliers located? |
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