Current Trends in Mass Spectrometry e-newsletter:
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November 3, 2015
Presented by LCGC and Spectroscopy
Featured Articles
Comprehensive Multilevel Characterization of Biologics Using Sheathless Capillary Electrophoresis Hyphenated to Tandem Mass Spectrometry
An analytical methodology for the characterization of the primary structure of biotherapeutic proteins using sheathless CE–ESI-MS-MS instrumentation is presented. For the first time, complete sequence coverage can be achieved using a bottom-up proteomic approach from a single analysis of a tryptic digest. In a biosimilarity assessment, a single amino acid substitution was detected.
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What’s the Most Meaningful Standard for Mass Spectrometry: Instrument Detection Limit or Signal-to-Noise Ratio?
Do the signal-to-noise ratios presented by instrument vendors accurately reflect improvements in mass spectrometers? We review factors influencing the validity of vendor SNR specifications, and argue that the statistical alternative of instrument detection limits is more consistent with regulatory guidelines and a more relevant indicator of instrument performance.
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Combining Thermal Desorption GC and TOF-MS for the Determination of Melon VOC Profiles
A method based on thermal desorption with gas chromatography–time-of-flight mass spectrometry (GC–TOF-MS) can elucidate how key volatiles vary with the size of the melon pieces. Such analytical information is of value in efforts to improve the quality and safety of ready-to-eat foods.
MS Detection of Waste in Public Swimming Facilities
Is your swimming pool clean and safe? Recreational water illness, most commonly in the form of digestive tract illness or skin, ear, or respiratory infections, is often caused by water contamination. The authors present a robust method, using solid-phase extraction and high-resolution mass spectrometry, for monitoring swimming pool water.
Featured Products
Improve Your Operation… Spellman’s MX10Plus Module
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Q Exactive Focus Orbitrap MS Redefining LC-MS/MS Performance
The Thermo Scientific™ Q Exactive™ Focus mass spectrometer is the newest addition to the impressive Q Exactive family, enabling highly selective quantitative and qualitative analysis in a single, affordable system.
Learn more 		Shimadzu’s new LCMS-8060 offers unmatched ultrafast technologies, a redesigned ion optical system, and outstanding durability to expand the limits of LC-MS/MS quantitation and achieve new levels of data quality.
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New Webcast

Making Ion Mobility Mass Spectrometry Routine
Wednesday, November 18, 2015
11 am EST / 4 pm GMT / 5 pm CET
 
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