Current Trends in Mass Spectrometry e-newsletter:
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May 25, 2016
Presented by LCGC and Spectroscopy
Featured Articles
Simplifying Mass Spectrometry Through New Ionization Technology: Application to Drugs and Clinical Analyses
A newly discovered method, matrix-assisted ionization (MAI), is described for generating gas-phase ions from volatile and nonvolatile compounds. The method is both simple and sensitive.
Analysis of Nicotine Alkaloids and Impurities in Liquids for e-Cigarettes by LC–MS, GC–MS, and ICP-MS
The development of various analytical MS methods to investigate the chemical composition of liquids used in electronic cigarettes and characterize their quality is presented in this study.
2D-LC–MS for the Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates in a Regulated Environment
High-resolution mass spectrometry (MS) is not readily compatible with chromatographic techniques using high-salt mobile phases. This study presents the development and use of 2D-LC–MS via an on-line desalting step for the analysis of monoclonal antibodies and antibody–drug conjugates.
Application note
Switch from Helium to Hydrogen
Helium, a common carrier gas for gas chromatography, is becoming increasingly expensive. Today, chromatographers choose to switch to hydrogen, an inexpensive and reliable gas source. Read More
Rapid Quantification of Trypsin Inhibitors in Food and Feed Formulations with Electrospray Ionization Mass Spectrometry
Measuring trypsin inhibitors in legumes is important to feed processors, who are concerned with providing high-quality products for animal feed. In this study, a rapid, accurate, and precise method for the quantification of trypsin inhibitor activity is evaluated.
The Role of Liquid Chromatography–Mass Spectrometry in the Characterization of Therapeutic Monoclonal Antibodies
A review of the central role LC–MS plays in characterizing mAbs and biosimilars, including highlights of top-down and middle-up approaches to measure the intact masses of mAbs and their subunits, the current state of peptide mapping techniques, and glycoprofiling methods.
Featured Products
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New Webcasts

High-Resolution Quantitative Characterization of Intact Biopharmaceuticals and Their Proteoforms
Wednesday, May 25, 2016
8 am PDT | 11 am EDT | 4 pm BST | 5 pm CEST

The Main Causes of Laboratory Water Contamination and Strategies to Avoid Them
Tuesday, June 14, 2016
8 am PDT | 11 am EDT | 4 pm BST | 5 pm CEST

Pesticide Residue Analysis Webinar: GC–MS-MS-Based Multi-Residue Determination of Pesticides in Difficult Matrices
Wednesday, July 13, 2016
8 am PDT/ 10 am CDT/ 11 am EDT/ 4 pm BST/ 5 pm CEST