Featured Articles
A new peptide mapping method was developed specifically for mAb characterization that employs optimal enzyme pH for robustness, but with short digestion times and time-course elements to minimize and monitor deamidation–isomerization, respectively, enabling a more accurate assessment of potential CDR sequence liabilities. read more
With this method, a single injection was sufficient to characterize the amino acid sequence with complete sequence coverage. In addition, glycosylation and drug-loaded peptides could be identified from MS/MS spectra. A drug-loaded peptide fragmentation mass spectra study yielded drug-specific fragments, which reinforced the confidence about the identifications. The results reveal the ability of the sheathless CZE–MS/MS method to characterize an ADC's primary structure in a single experiment. read more
When adhering to sound analytical principles, the inclusion of mass spectrometry in the clinical laboratory can lead to accurate, selective, and precise quantitative methods by detecting new classes of compounds with greater efficiency and sensitivity than is possible with older, established technologies. read more
A brief preview of this year's ASMS conference, taking place June 4–8, 2017, in Indianapolis, Indiana. read more
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Highly accurate standard addition and generation of standards and dilution series can significantly improve the quality of analysis results. Useful tools and techniques include the Accurate Add function for improved sampler precision; thermostating; and weighing – as well as vial venting to eliminate pressure build-up.  Read more
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