Featured Articles

Detection and Characterization of Extractables in Food Packaging Materials by GC–MS

In this study, general extract screening of food storage materials was done with nontargeted analytical methods to understand what analytes could potentially leach into food or beverages. GC and mass spectral deconvolution effectively separated analytes within the complex mixture and TOF-MS provided full mass range spectral data for identification. This workflow can be used for confident characterization of components present as extractables from food packaging materials. read more

Application note

Drugs in Saliva by SPE-LC-MS/MS

An existing SPE-LC-MS/MS method for 50+ drugs of abuse and their analogues in saliva was automated and miniaturized. The required limits of detection were met with providing good linearity, accuracy and precision. No carryover was seen. Read more

Determination of Very Low Abundance Diagnostic Proteins in Serum Using Immunocapture LC–MS/MS

There is growing interest in the determination of endogenous proteins in biological samples for diagnostic purposes, because a concentration increase or decrease of such proteins can allows us to monitor the state of a pathological condition such as cancer. Immunocapture LC–MS/MS analysis combines the workflow of conventional immunological assays with LC–MS analysis. This article describes typical challenges, such as cross reactivity and the mass spectrometer's dynamic range, as well as the advantages of isoform differentiation and multiplexing. read more