In our February issue:
COLUMNS
Molecular Spectroscopy Workbench
Raman Polarization Measurements: Keeping Track of the Instrumental Components’ Behavior
Fran Adar
Controlling the orientation of the laser and Raman polarization relative to the sample orientation can provide a wealth of information. But it is easy to produce erroneous results, so you need to know what instrumental components affect the observed polarization effects and how the sample setup itself affects the Raman signal.
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Chemometrics in Spectroscopy
Bias and Slope Correction
Jerome Workman Jr. and Howard Mark
Bias and slope adjustments are the most bothersome issues associated with the routine use of multivariate models for quantitative analysis in spectroscopy. Here, we delve into the issues causing prediction error, bias, and slope changes.
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Focus on Quality
Understanding Data Governance, Part I
R.D. McDowall
Data governance to ensure GXP data integrity requires a multilayered approach that runs throughout a regulated organization. Here in Part I of this two-part article, we consider data integrity from the corporate level.
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Peer-Reviewed Articles
Frontiers of Far-Ultraviolet Spectroscopy in the Solid and Liquid States
Yukihiro Ozaki
Far-UV spectroscopy holds considerable promise not only in basic science—such as for studies of the electronic structure of molecules, hydrogen bonding, and adsorption of water and aqueous solutions—but also for practical applications such as on-line analysis, geochemical and environmental analysis, semiconductor research, and surface analysis.
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Developing Portable Raman Spectroscopy Methods for Identification of Raw Materials Used in Pharmaceutical Development and Manufacturing
Michael A. Dotlich and Indrajit Giri
Great care is required when developing Raman spectral libraries for raw material identification. Critical factors—such as instrument type, Raman capability, container type, container interference, background interference, and material variability—can potentially influence the identity of the material.
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