Spectroscopy Spotlight

Measuring Isotopic Compositions with Multiple-Collector ICP-MS: The Only Limit Is the Imagination

Multiple-collector inductively coupled plasma–mass spectrometry (MC-ICP-MS) is a powerful technique for measuring isotopic ratios in various areas of research. Michael Wieser, who is an associate professor in the Department of Physics and Astronomy at the University of Calgary, uses MC-ICP-MS to measure isotopic compositions at trace levels in applications ranging from geological studies to protein research. He recently spoke to Spectroscopy about this work. read more

Featured Articles

Bias and Slope Correction

Bias and slope adjustments are the most bothersome issues associated with the routine use of multivariate models for quantitative analysis in spectroscopy. Here, we delve into the issues causing prediction error, bias, and slope changes. read more

Understanding Data Governance, Part I

Data governance to ensure GXP data integrity requires a multilayered approach that runs throughout a regulated organization. Here in Part I of this two-part article, we consider data integrity from the corporate level. read more

Quantitation of Albumin and Creatinine in Urine by MALDI-TOF Mass Spectrometry

This MS-based method represents a simple, fast, and attractive alternative to current immunoassay-based methods for the quantitation of albumin and creatinine in urine. This protocol enables the direct detection and measurement of the intact analytes from the same sample preparation, requiring only a 10-fold dilution of a urine sample into a MALDI-TOF matrix solution. read more