Featured Articles

Epitope Mapping of an Interleukin Receptor for Three Therapeutic Antibodies by Hydrogen-Deuterium Exchange Mass Spectrometry

Among all the analytical techniques available for epitope mapping studies, hydrogen–deuterium exchange mass spectrometry (HDX-MS) is usually the fastest and easiest to carry out. We present here the epitope mapping of three distinct monoclonal antibody (mAb) candidates targeting the same antigen, an interleukin receptor. The goal is to establish the binding mode of these mAbs, and explain possible differences observed for in vitro binding and in vivo function. read more

Research-grade Q-TOF LCMS

Shimadzu's LCMS-9030 Q-TOF mass spectrometer combines the engineering DNA from our proven LC-MS/MS platform with powerful new TOF architecture to transform high mass accuracy workflows. Data acquisition and analysis control software provides researchers with easy, yet flexible workflows. The result is a system that delivers high-resolution, accurate-mass detection with incredibly fast data acquisition rates, allowing you to perform critical analysis with confidence. Learn more

Enhancing the Sensitivity of Atmospheric Pressure Ionization Mass Spectrometry Using Flow Modulated Gas Chromatography

The past decade has witnessed resurgent interest in coupling GC to atmospheric-pressure chemical ionization (APCI), which is suitable for the high column flows required for using flow modulation. This study assesses the use of GP-APCI with flow modulation for sensitive detection of selected trace organics. read more