October 2011


October 2011	Subscribe	Go to Application Notebook

High Speed Protein Identification in Complex Matrices
Eric Johansen, Xu Guo, Scott Stuart, Sean L. Seymour, Doug Simmons, and Christie L. Hunter, AB SCIEX
It is now possible to analyze complex samples in proteomics research using mass spectrometric techniques. The TripleTOF™ 5600 system achieves this with high acquisition speeds, high resolution, and high mass accuracy.

MSMS^ALL with SWATH Acquisition
Stephen Tate and Christie Hunter, AB SCIEX
In many samples, the complexity and dynamic range of compounds is very large posing challenges for analysis. MSMS^ALL with SWATH Acquisition enables comprehensive acquisition and targeted quantification for the highest quality data.

Introduction to the Analysis of Intact Proteins
Doug Simmons, AB SCIEX
The analysis of intact proteins by accurate mass LC–MS by the TripleTOF^TM 5600 is the method of choice for determining intact mass, protein heterogeneity, and post-translational modifications.

Peptide Quantification and Identification Using High Resolution MS
Brigitte Simons, AB SCIEX
Protein quantification based on mass spectral data falls into two categories: MS-MS, and MS-based approaches. With the TripleTOF™ 5600 system, all of these workflows can be performed on a single instrument.

SelexION Technology: A New Solution to Selectivity Challenges
Yves LeBlanc, Doina Caraiman, Mauro Aiello, and Hesham Ghobarah, AB SCIEX
High selectivity is a key component of successful quantitative bioanalysis. The SelexION™ technology with the QTRAP^® 5500 system brings the power of differential ion mobility separation to complex bioanalysis.

Simultaneous Pharmacokinetic Profiling and Automated Metabolite Identification
Suma Ramagiri, Jeff Miller, and Hesham Ghobarah, AB SCIEX
Combining quantitative bioanalysis and in vivo metabolite identification has the potential to significantly increase the productivity of pharmaceutical drug discovery. Using the TripleTOF™ 5600 system enables simultaneous in vivo PK quantification and identification.

LC–MS-MS Analysis of Amphetamines in Urine
Adam Latawiec and Adrian Taylor, AB SCIEX
LC–MS-MS is a reliable method to perform screening and confirmation of drugs in urine without the setup requirements of immunoassays or time-consuming sample preparation and derivatization required for GC–MS confirmation.

LC–MS-MS Analysis of Cannabinoids, Opiates, and Cocaine in Urine
John McFarlane and Adrian Taylor, AB SCIEX
The described method provides an effective means to detect, confirm, and quantify drugs of abuse in urine at or below the typical GC–MS cutoff values.

Targeted and Non-Targeted Screening for Drugs
Adrian Taylor, Michael Jarvis, and Brad Patterson, AB SCIEX
The high resolution and accurate mass TripleTOF™ 5600 system was used to screen drugs from both forensic equine and forensic toxicology urine, and to quantify drug compounds with excellent accuracy and high reproducibility.

Quantification of Steroids and Vitamin D3 in Dried Blood Spots
Theresa Lee, Susan Leonard, and Hua-Fen Liu, AB SCIEX
This technical note highlights a simple method requiring no derivatization of target compounds, which is capable of measuring a variety of steroids from DBS and serum using LC–MS-MS.

Simultaneous Detection and Confirmation of Antifungals and Immunosuppressant Drugs
Fabienne Le Floch, AB SCIEX
This technical note describes a rapid, robust, sensitive, and cost effective quantitation method for four immunosuppressive drugs and simultaneous detection and confirmation of five azole antimycotics in whole blood.

Target and Non-Target Screening for Pesticide Residues in Food Samples
André Schreiber and Christopher Borton, AB SCIEX
The TripleTOF™ 5600 System was used to screen and quantify for pesticide residues in extracts of fruit and vegetables. The identity and quantification of both known and unknown compounds were confirmed.

Quantitation and Identification of Melamine and Cyanuric Acid in Pet Food
Takeo Sakuma, Adrian Taylor, and André Schreiber, AB SCIEX
A fast and sensitive LC–MS-MS method was developed for the analysis of melamine and cyanuric acid, and provides an extra degree of confidence through the use of multiple reaction monitoring (MRM) ratios for compound identification.

Contact Editor - Meg Evans

You are subscribed to %%list.name%% as %%emailaddr%%. To unsubscribe from this list click here.

To ensure delivery to your Inbox, please add %%email.list%% to your address book. If you need help doing this, click here.

Advanstar Communications provides certain customer contact data (such as customers' names, addresses, phone numbers and e-mail addresses) to third parties who wish to promote relevant products, services and other opportunities which may be of interest to you. If you do not want Advanstar Communications to make your contact information available to third parties for marketing purposes, simply call (toll free) 1-866-529-2922 at any time, or fax us at 1-218-740-6417. Outside the U.S., please phone 1-218-740-6395. Contact us by mail at Advanstar Communications Inc., 131 West First St., Duluth, MN 55802-2065, USA.