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CHROMacademy Newsletter
27 March 2018
 
 
HPLC Troubleshooting Guide – Peak Tailing
 
Tailing peaks create issues with resolution, quantitation (integration), and reproducibility. Peak shape is often the controlling factor when optimizing complex separations, especially when components are present in very different concentrations...
 
 
 
 
 
 
SPE Procedure Optimization
 
In recent Quick Guides we have looked at the steps involved in solid phase extraction method development; analyte assessment, mechanism selection, and sorbent screening. The final step is procedure optimization...
 
 
 
 
 
 
A Little Bit of Split
 
Practical GC tips and tricks to help improve your analyses. The benefits of using a little bit of split, instead of splitless injection, without sacrificing sensitivity for low concentration samples.
 
 
 
 
 
 
Autosampler Contamination
 
Contamination in any chromatographic method is a complex problem to troubleshoot. Extra peaks, often referred to as ghost peaks, in a blank or sample chromatogram can have a number of sources...
 
 
 
 
 
 
Peak Purity Algorithms using Diode
Array Detectors
 
In an ideal chromatographic separation, all sample components would be isolated from each other and detected as fully resolved peaks...
 
 
 
 
 
Featured Quick Guides
 
Fundamentals of GC-MS Ionization Techniques
GC-MS Leak Detection
Does Mass Spectrometry Need Chromatography?
 
 
Featured eLearning Modules
 
The Theory of HPLC - Reversed Phase Chromatography
Theory and Instrumentation of GC - Sample Introduction
Solid Phase Extraction - Liquid / Liquid Extraction Techniques
 
 
Featured Webcasts
 
Understanding Electrospray Ionization (ESI) for LC-MS
GC-MS Ionization Processes
 
 
 
 
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